Evidence map›Paper›PMID 33153072›Full record

ArticleCells2020

Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.

Yuqing Wu, Cao Li, Huiming Peng, Ashraf Swaidan, Andrea Riehle, Barbara Pollmeier, Yang Zhang, Erich Gulbins, Heike Grassmé

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  3. Article
  4. Article
  5. Frontiers in cellular and infection microbiology · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Yuqing WuDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Cao LiDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Huiming PengDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Ashraf SwaidanDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Andrea RiehleDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Barbara PollmeierDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Yang ZhangDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, 3517 Cullen Blvd, Houston, TX 77204-5056, USA.
Erich GulbinsDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Heike GrassméDepartment of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
University of Duisburg-Essen · DEBeijing Tian Tan Hospital · CNSabin Vaccine Institute · USUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis, caused by

Indexed as

AnimalsCathepsin DEndocytosisMacrophagesMice, Inbred C57BLModels, BiologicalMycobacterium bovisNADPH OxidasesReactive Oxygen SpeciesSignal TransductionSphingomyelin PhosphodiesteraseTuberculosisUp-RegulationCathepsin DNADPH OxidasesReactive Oxygen SpeciesSphingomyelin Phosphodiesteraseacid sphingomyelinase (Asm)cathepsin D (CTSD)ceramidegranulomamacrophagesMycobacterium bovis Bacillus Calmette-Guérin (BCG)reactive oxygen species (ROS)

Identifiers

PMID33153072
PMCPMC7693114
OpenAlexW3097158603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.