ArticleInternational journal of molecular sciences2020
Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparison of Bacterial Adhesion on Two Different Suture Materials After Tooth Extraction in Women Receiving Antiresorptive Therapy: An Exploratory Clinical Study with Prospective Data Collection.Journal of clinical medicine · 2026Article
- Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Microbial Changes in the Periodontal Environment Due to Orthodontic Appliances: A Review.Cureus · 2024Review
- The tongue microbiome of young patients with chronic kidney disease and their healthy mothers.Clinical oral investigations · 2024Article
- Characterization and morphological methods for oral biofilm visualization: where are we nowadays?AIMS microbiology · 2024Review
- The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review.Biomedicines · 2023Review
- Impact of Clear Aligners on Oral Health and Oral Microbiome During Orthodontic Treatment.International dental journal · 2023Review
- Orofacial clefts alter early life oral microbiome maturation towards higher levels of potentially pathogenic species: A prospective observational study.Journal of oral microbiology · 2023Article
- Managing Oral Health in the Context of Antimicrobial Resistance.International journal of environmental research and public health · 2022Review
- Oral Microbiota and Tumor-A New Perspective of Tumor Pathogenesis.Microorganisms · 2022Review
- Article
- Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?iScience · 2022Review
- Review
- Orofacial clefts lead to increased pro-inflammatory cytokine levels on neonatal oral mucosa.Frontiers in immunology · 2022Article
- Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies.Frontiers in immunology · 2021Review
- Investigation of the impact of commonly used medications on the oral microbiome of individuals living without major chronic conditions.PloS one · 2021Article
- Acute Radiation Syndrome and the Microbiome: Impact and Review.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human oral microbiota consists of over 700 widespread taxa colonizing the oral cavity in several anatomically diverse oral niches. Lately, sequencing of the 16S rRNA genes has become an acknowledged, culture-independent method to characterize the oral microbiota. However, only a small amount of data are available concerning microbial differences between oral niches in periodontal health and disease. In the context of periodontitis, the cytokine expression in the gingival crevicular fluid has been studied in detail, whereas little is known about the cytokine profile in hard and soft tissue biofilms. In order to characterize oral niches in periodontal health, the oral microbiota and cytokine pattern were analyzed at seven different sites (plaque (P), gingival crevicular fluid (GCF), saliva (S), tongue (T), hard palate (HP), cheek (C) and sublingual area (U)) of 20 young adults using next-generation sequencing and multiplex immunoassays. Site-specific microbial compositions were detected, which clustered into three distinct metaniches ("P-GCF", "S-T-HP" and "C-U") and were associated with niche-/metaniche-specific cytokine profiles. Our findings allow the definition of distinct metaniches according to their microbial composition, partly reflected by their cytokine profile, and provide new insights into microenvironmental similarities between anatomical diverse oral niches.
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