Evidence map›Paper›PMID 33152556›Full record

ReviewCurrent opinion in cell biology2020

Integrating cellular dimensions with cell differentiation during early development.

Hui Chen, Wenchao Qian, Matthew C Good

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hui ChenDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenchao QianDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew C GoodDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mattgood@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Regulation of the Timing and Spatial Patterning of Zygotic Genome Activation During EmbryogenesisR35GM128748 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOOD, MATTHEW CHARLTON · 2018 to 2022
$2.0M
Exploiting Masked Alcohols to Guide Atom-Transfer ReactionsR35GM128741 · NIGMS · DUKE UNIVERSITY · PI ROIZEN, JENNIFER L · 2018 to 2020
$1.2M
NIGMS NIH HHS R35 GM128748
6 · The paper itself

Abstract

Early embryo development is characterized by alteration of cellular dimensions and fating of blastomeres. An emerging concept is that cell size and shape drive cellular differentiation during early embryogenesis in a variety of model organisms. In this review, we summarize recent advances that elucidate the contribution of the physical dimensions of a cell to major embryonic transitions and cell fate specification in vivo. We also highlight techniques and newly evolving methods for manipulating the sizes and shapes of cells and whole embryos in situ and ex vivo. Finally, we provide an outlook for addressing fundamental questions in the field and more broadly uncovering how changes to cell size control decision making in a variety of biological contexts.

Indexed as

Cell DifferentiationEmbryonic DevelopmentAnimalsCell LineageCell SizeEmbryo, MammalianHumansModels, BiologicalCell cycle elongationCell differentiationCell fateCell shapeCell sizeCellular dimensionsDNA:Cytoplasm ratioEmbryo sizeNucleocytoplasmic ratioZGAZygotic genome activation

Identifiers

PMID33152556
PMCPMC8212396
OpenAlexW3097755208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.