Evidence map›Paper›PMID 33152515›Full record

ReviewExperimental gerontology2020

Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.

Stephanie M Muscat, Ruth M Barrientos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Finding a fountain of youth in the blood.Journal of thrombosis and haemostasis : JTH · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephanie M MuscatInstitute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, USA.
Ruth M BarrientosInstitute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA; Chronic Brain Injury Program, Discovery Themes Initiative, The Ohio State University, Columbus, OH, USA. Electronic address: ruth.barrientos@osumc.edu.

Funding

Neuroinflammation, Inflammatory Challenge, and MemoryR01AG028271 · NIA · UNIVERSITY OF COLORADO · PI MAIER, STEVEN F · 2006 to 2016
$3.8M
Neuroinflammation, Inflammatory Challenge, and MemoryRF1AG028271 · NIA · UNIVERSITY OF COLORADO · PI BARRIENTOS, RUTH M, MAIER, STEVEN F · 2018 to 2021
$2.4M
Exploring HFD-induced alterations in long-term potentiation in aged hippocampus and amygdalaR03AG067061 · NIA · OHIO STATE UNIVERSITY · PI BARRIENTOS, RUTH M · 2020 to 2021
$156k
NIA NIH HHS R01 AG028271NIA NIH HHS R03 AG067061NIA NIH HHS RF1 AG028271
6 · The paper itself

Abstract

Aging-associated microglial priming results in the potential for an exaggerated neuroinflammatory response to a subsequent inflammatory challenge in regions of the brain known to support learning and memory. This excessive neuroinflammation in the aging brain is known to occur following a variety of peripheral insults, including infection and surgery, where it has been associated with precipitous declines in cognition and memory. As the average lifespan increases worldwide, identifying interventions to prevent and treat aging-associated excessive neuroinflammation and ensuing cognitive impairments is of critical importance. Lifestyle has emerged as a potential non-pharmacological target in this endeavor. Here, we review important and recent preclinical and clinical literature demonstrating the anti-inflammatory effects of lifestyle modifications such as exercise, diet, and environmental enrichment in the context of aging and memory. Importantly, we focus on research indicating that these lifestyle modifications do not need to be lifelong, suggesting that such interventions may be efficacious in the prevention and treatment of aging- and neuroinflammation-associated cognitive impairment, even when initiated in older age.

Indexed as

HippocampusMicrogliaLife StyleMemoryAgingDietEnvironmental enrichmentExerciseLifestyleNeuroinflammationPost-operative cognitive dysfunction

Identifiers

PMID33152515
PMCPMC7704639

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.