Evidence map›Paper›PMID 33152493›Full record

ArticleWorld neurosurgery2021

Convexity Meningiomas in Patients with Neurofibromatosis Type 2: Long-Term Outcomes After Gamma Knife Radiosurgery.

Henry Ruiz-Garcia, Daniel M Trifiletti, Nasser Mohammed, Yi-Chieh Hung, Zhiyuan Xu, Tomas Chytka, Roman Liscak, Manjul Tripathi, David Arsanious, Christopher P Cifarelli and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Henry Ruiz-GarciaDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA; Department of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA.
Daniel M TrifilettiDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA; Department of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA.
Nasser MohammedDepartment of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Yi-Chieh HungDepartment of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Zhiyuan XuDepartment of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Tomas ChytkaDepartment of Neurological Surgery, Na Homolce Hospital, Prague, Czech Republic.
Roman LiscakDepartment of Neurological Surgery, Na Homolce Hospital, Prague, Czech Republic.
Manjul TripathiPost Graduate Institute of Medical Education and Research, Chandigarh, India.
David ArsaniousDepartment of Neurological Surgery, West Virginia University, Morgantown, Virginia, USA.
Christopher P CifarelliDepartment of Neurological Surgery, West Virginia University, Morgantown, Virginia, USA.
Marco Perez CaceresDepartment of Neurological Surgery, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
David MathieuDepartment of Neurological Surgery, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Herwin SpeckterDominican Gamma Knife Center and CEDIMAT Hospital, Santo Domingo, Dominican Republic.
Gregory P LekovicHouse Ear Institute, Los Angeles, California, USA.
Gautam U MehtaHouse Ear Institute, Los Angeles, California, USA.
Jason P SheehanDepartment of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA. Electronic address: jsheehan@virginia.edu.
Neurological Surgery · USHouse Clinic · USJacksonville College · USNa Homolce Hospital · CZUniversité de Sherbrooke · CAWest Virginia University · USInstituto Tecnológico de Santo Domingo · DOPost Graduate Institute of Medical Education and Research · IN

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

backgroundConvexity meningiomas are common tumors requiring treatment in patients with neurofibromatosis type 2 (NF2). Although different therapeutic options are described for sporadic convexity meningioma, much less is known about these lesions in patients with NF2 despite their distinct biology and need for multiple treatments. We analyzed the value of Gamma Knife radiosurgery (GKRS) as definitive treatment for convexity meningiomas in patients with NF2.

methodsThis international multicenter retrospective study was approved by the International Radiosurgery Research Foundation. Patients with NF2 with at least 1 convexity meningioma and 6-month follow-up after primary GKRS were included.

resultsInclusion criteria were met by 18 patients with NF2. A total of 120 convexity meningiomas (median treatment volume, 0.66 cm

conclusionsGKRS is safe and effective as definitive treatment of small to medium-sized convexity meningiomas in patients with NF2. Despite concerns about the particular mutational burden of these tumors, no malignant transformation manifested after treatment. GKRS represents a minimally invasive option that offers long-term tumor control to this specific group of patients.

Indexed as

AdolescentAdultBrain EdemaFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasms, Multiple PrimaryNeurofibromatosis 2Progression-Free SurvivalRadiosurgeryRetrospective StudiesTreatment OutcomeTumor BurdenConvexityGamma Knife radiosurgeryMeningiomaNeurofibromatosis type 2

Identifiers

PMID33152493
PMCPMC7988886
OpenAlexW3096542375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.