ReviewBrain, behavior, and immunity2021
Prenatal exposure to viral infection and neuropsychiatric disorders in offspring: A review of the literature and recommendations for the COVID-19 pandemic.
Review in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Cortical Auditory Neural Responses to Speech and Communicative Functioning in Normocephalic Children With Prenatal Exposure to the Zika Virus.Ear and hearing · 2026Article
- Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence.International journal of molecular sciences · 2025Review
- The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway.Journal of neuroinflammation · 2025Review
- Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned.Pediatric research · 2024Review
- Neonatal outcomes of maternal prenatal coronavirus infection.Pediatric research · 2024Review
- Microglia Modulate Neurodevelopment in Autism Spectrum Disorder and Schizophrenia.International journal of molecular sciences · 2023Review
- Long-term effects of prenatal infection on the human brain: a prospective multimodal neuroimaging study.Translational psychiatry · 2023Article
- Review
- Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials.Stem cell research & therapy · 2023Review
- Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy.JAMA network open · 2023Observational
- Exploring the impact of COVID-19 on newborn neurodevelopment: a pilot study.Scientific reports · 2023Article
- Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.Frontiers in pediatrics · 2023Article
- Developing brain under renewed attack: viral infection during pregnancy.Frontiers in neuroscience · 2023Review
- Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge.Frontiers in neuroscience · 2023Review
- Maternal Mental Health and Infant Development During the COVID-19 Pandemic.JAMA psychiatry · 2022Article
- Emerging Knowledge of the Neurobiology of COVID-19.The Psychiatric clinics of North America · 2022Review
- Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of theFrontiers in pediatrics · 2022Article
- Maternal immune activation as a risk factor for psychiatric illness in the context of the SARS-CoV-2 pandemic.Brain, behavior, & immunity - health · 2021Article
- Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders.International journal of molecular sciences · 2021Review
- [Consequences of the COVID-19 pandemic for people with schizophrenia, dementia and substance use disorders].Der Nervenarzt · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The SARS-CoV-2 virus has emerged as a striking 21st century pandemic. Communities across the globe have experienced significant infection rates and widespread psychosocial stress and trauma, leading to calls for increased allocation of resources for mental health screening and treatment. In addition to the burden of psychosocial stress, there is increasing evidence of direct viral neuroinvasion of the central nervous system through physical contact with the nasal mucosa. In a parallel fashion, there is a significant body of ongoing research related to the risk of in utero viral transmission and the resulting neurodevelopmental impact in the fetus. Aberrant neurodevelopment secondary to viral transmission has previously been related to the later development of psychosis, schizophrenia, and schizophrenia spectrum disorders, generating the hypothesis that this population of individuals exposed to SARS-CoV-2 may see an increased incidence in future decades. We discuss the current understanding of the possible neurotropism and vertical transmission of SARS-CoV-2, and relate this to the history of viral pandemics to better understand the relationship of viral infection, aberrant immune response and neurodevelopment, and the risk for schizophrenia disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.