Evidence map›Paper›PMID 33152415›Full record

ArticleInternational journal of cardiology2021

Left ventricular systolic dysfunction identification using artificial intelligence-augmented electrocardiogram in cardiac intensive care unit patients.

Jacob C Jentzer, Anthony H Kashou, Zachi I Attia, Francisco Lopez-Jimenez, Suraj Kapa, Paul A Friedman, Peter A Noseworthy

Abstract read
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In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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  3. New Insights into Cardiac Intensive Care.Reviews in cardiovascular medicine · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jacob C JentzerDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States of America; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States of America. Electronic address: jentzer.jacob@mayo.edu.
Anthony H KashouDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Kashou.Anthony@mayo.edu.
Zachi I AttiaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: attia.itzhak@mayo.edu.
Francisco Lopez-JimenezDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: lopez@mayo.edu.
Suraj KapaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Kapa.Suraj@mayo.edu.
Paul A FriedmanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Friedman.Paul@mayo.edu.
Peter A NoseworthyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Noseworthy.Peter@mayo.edu.
Mayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn artificial intelligence-augmented electrocardiogram (AI-ECG) can identify left ventricular systolic dysfunction (LVSD). We examined the accuracy of AI ECG for identification of LVSD (defined as LVEF ≤40% by transthoracic echocardiogram [TTE]) in cardiac intensive care unit (CICU) patients.

methodWe included unique Mayo Clinic CICU patients admitted from 2007 to 2018 who underwent AI-ECG and TTE within 7 days, at least one of which was during hospitalization. Discrimination of the AI-ECG for LVSD was determined using receiver-operator characteristic curve (AUC) values.

resultsWe included 5680 patients with a mean age of 68 ± 15 years (37% females). Acute coronary syndrome (ACS) was present in 55%. LVSD was present in 34% of patients (mean LVEF 48 ± 16%). The AI-ECG had an AUC of 0.83 (95% confidence interval 0.82-0.84) for discrimination of LVSD. Using the optimal cut-off, the AI-ECG had 73%, specificity 78%, negative predictive value 85% and overall accuracy 76% for LVSD. AUC values were higher for patients aged <70 years (0.85 versus 0.80), males (0.84 versus 0.79), patients without ACS (0.86 versus 0.80), and patients who did not undergo revascularization (0.84 versus 0.80).

conclusionsThe AI-ECG algorithm had very good discrimination for LVSD in this critically-ill CICU cohort with a high prevalence of LVSD. Performance was better in younger male patients and those without ACS, highlighting those CICU patients in whom screening for LVSD using AI ECG may be more effective. The AI-ECG might potentially be useful for identification of LVSD in resource-limited settings when TTE is unavailable.

Indexed as

Artificial IntelligenceVentricular Dysfunction, LeftAgedAged, 80 and overEchocardiographyElectrocardiographyFemaleHumansIntensive Care UnitsMaleMiddle AgedArtificial intelligenceCardiac intensive care unitEchocardiographyElectrocardiogramLeft ventricular dysfunction

Identifiers

PMID33152415
OpenAlexW3096743003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.