Observational studyThe Journal of pediatrics2021
Loop Diuretics in Severe Bronchopulmonary Dysplasia: Cumulative Use and Associations with Mortality and Age at Discharge.
Observational study in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?Current treatment options in pediatrics · 2026Article
- Maternal low sodium intake and early postnatal diuretics program metabolic and ventilatory dysfunction in mice.Pediatric research · 2026Article
- Population Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.Journal of clinical pharmacology · 2026Article
- Characteristics associated with death or tracheostomy in infants with bronchopulmonary dysplasia following predominant non-invasive respiratory support.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pulmonary vasodilator use in very preterm infants in United States children's hospitals.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants.Paediatric drugs · 2025Review
- Association of furosemide versus chlorothiazide exposures with serum sodium, potassium, and chloride among infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Diuretic Tolerance to Repeated-Dose Furosemide in Infants Born Very Preterm with Bronchopulmonary Dysplasia.The Journal of pediatrics · 2024Article
- Diuretic drug utilization in neonates: a French prescription database analysis.Frontiers in pharmacology · 2024Article
- Positive fluid balance and diuretic therapy are associated with mechanical ventilation and mortality in preterm neonates in the first fourteen postnatal days.Pediatric nephrology (Berlin, Germany) · 2023Article
- Diuretics in pediatrics.European journal of pediatrics · 2023Review
- Disparities in Lung Disease of Prematurity-When Does Exposure to Racism Begin?JAMA pediatrics · 2022Article
- Association between postmenstrual age and furosemide dosing practices in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
- Pharmacotherapy in Bronchopulmonary Dysplasia: What Is the Evidence?Frontiers in pediatrics · 2022Review
- Diuretic use, acute kidney injury, and premature infants: the call for evidence-based guidelines.Pediatric nephrology (Berlin, Germany) · 2021Article
- In-hospital outcomes of late referrals for established bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Evidence for the Management of Bronchopulmonary Dysplasia in Very Preterm Infants.Children (Basel, Switzerland) · 2021Review
- An Update on the Prevention and Management of Bronchopulmonary Dysplasia.Pediatric health, medicine and therapeutics · 2021Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo measure between-center variation in loop diuretic use in infants developing severe bronchopulmonary dysplasia (BPD) in US children's hospitals, and to compare mortality and age at discharge between infants from low-use centers and infants from high-use centers. STUDY
designWe performed a retrospective cohort study of preterm infants at <32 weeks of gestational age with severe BPD. The primary outcome was cumulative loop diuretic use, defined as the proportion of days with exposure between admission and discharge. Infant characteristics associated with loop diuretic use at P < .10 were included in multivariable models to adjust for center differences in case mix. Hospitals were ranked from lowest to highest in adjusted use and dichotomized into low-use centers and high-use centers. We then compared mortality and postmenstrual age at discharge between the groups through multivariable analyses.
resultsWe identified 3252 subjects from 43 centers. Significant variation between centers remained despite adjustment for infant characteristics, with use present in an adjusted mean range of 7.3% to 49.4% of days (P < .0001). Mortality did not differ significantly between the 2 groups (aOR, 0.98; 95% CI, 0.62-1.53; P = .92), nor did postmenstrual age at discharge (marginal mean, 47.3 weeks [95% CI, 46.8-47.9 weeks] in the low-use group vs 47.4 weeks [95% CI, 46.9-47.9 weeks] in the high-use group; P = .96).
conclusionsA marked variation in loop diuretic use for infants developing severe BPD exists among US children's hospitals, without an observed difference in mortality or age at discharge. More research is needed to provide evidence-based guidance for this common exposure.
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