Evidence map›Paper›PMID 33152312›Full record

ReviewThe Lancet. Oncology2020

Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.

Sriram Gubbi, Shilpa Thakur, Shirisha Avadhanula, Katherine A Araque, Armando C Filie, Mark Raffeld, James Welch, Jaydira Del Rivero, Electron Kebebew, Kenneth D Burman and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in The Lancet. Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Thyroid Leiomyoma: Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Sriram GubbiNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Shilpa ThakurNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Shirisha AvadhanulaDepartment of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Katherine A AraqueDepartment of Endocrinology, Pacific Neuroscience Institute, John Wayne Cancer Institute, Santa Monica, CA, USA.
Armando C FilieNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark RaffeldNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
James WelchNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Jaydira Del RiveroNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Electron KebebewDepartment of General Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Kenneth D BurmanDepartment of Endocrinology, MedStar Washington Hospital Center, Washington, DC, USA.
Leonard WartofskyDepartment of Endocrinology, MedStar Health Research Institute, Washington, DC, USA.
Joanna Klubo-GwiezdzinskaNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: joanna.klubo-gwiezdzinska@nih.gov.
National Institutes of Health · USNational Cancer Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USCleveland Clinic · USMedStar Health · USMedStar Washington Hospital Center · USSaint John's Health Center · USStanford University · US

Funding

Studies of Benign and Malignant Thyroid DiseaseZIADK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2009 to 2025
$4.3M
Studies of Benign and Malignant Thyroid DiseaseZIEDK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2013 to 2020
$1.9M
Studies of Benign and Malignant Thyroid DiseaseZ01DK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SKARULIS, MONICA · 2008 to 2008
$693k
Intramural NIH HHS Z01 DK047053Intramural NIH HHS ZIA DK047053
6 · The paper itself

Abstract

Most primary thyroid tumours are of epithelial origin. Primary thyroid mesenchymal tumours are rare but are being increasingly detected. A vast majority of thyroid mesenchymal tumours occur between the fourth and seventh decades of life, presenting as progressively enlarging thyroid nodules that often yield non-diagnostic results or spindle cells on fine needle aspiration biopsy. Surgery is the preferred mode of treatment, with adjuvant chemoradiotherapy used for malignant thyroid mesenchymal tumours. Benign thyroid mesenchymal tumours have excellent prognosis, whereas the outcome of malignant thyroid mesenchymal tumours is variable. Each thyroid mesenchymal tumour is characterised by its unique histopathology and immunohistochemistry. Because of the rarity and aggressive nature of malignant thyroid mesenchymal tumours, a multidisciplinary team-based approach should ideally be used in the management of these tumours. Comprehensive guidelines on the management of thyroid mesenchymal tumours are currently lacking. In this Review, we provide a detailed description of thyroid mesenchymal tumours, their clinical characteristics and tumour behaviour, and provide recommendations for the optimal management of these tumours.

Indexed as

Biomarkers, TumorNeoplasms, Connective and Soft TissueThyroid NeoplasmsClinical Decision-MakingHumansPredictive Value of TestsPrognosisBiomarkers, Tumor

Identifiers

PMID33152312
PMCPMC9597611
OpenAlexW3096130448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.