ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021
Older age and male sex are associated with higher cerebrovascular impedance.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Exercise Training Reduces Cerebrovascular Impedance in Patients with Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial.Medicine and science in sports and exercise · 2026Trial
- Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Attenuated aortic-cerebral pulsatile transmission with posture-related increases in stroke volume in healthy young adults.European journal of applied physiology · 2026Article
- Exploring physiological factors underlying individual differences in exercise-induced blood pressure responses.Experimental physiology · 2026Article
- Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline.Experimental physiology · 2025Review
- Prolonged sitting is not associated with altered shear-mediated dilation of the internal carotid artery, despite impairing lower limb endothelial function.Physiological reports · 2025Article
- The time constant of the cerebral arterial bed: exploring age-related implications.Journal of clinical monitoring and computing · 2024Article
- Patients with amnestic mild cognitive impairment have higher cerebrovascular impedance than cognitively normal older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Does Cardiac Function Affect Cerebral Blood Flow Regulation?Journal of clinical medicine · 2022Review
- Association of Aortic Stiffness and Pressure Pulsatility With Global Amyloid-β and Regional Tau Burden Among Framingham Heart Study Participants Without Dementia.JAMA neurology · 2022Article
- Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Cerebral blood flow (CBF) becomes pulsatile in response to the pulsatile change in perfusion pressure that is regulated by cerebrovascular impedance. In this study, we aimed to characterize age-related differences in cerebrovascular impedance across the adult lifespan. Carotid artery pressure [(CAP), via applanation tonometry] and CBF velocity (CBFV) in the middle cerebral artery (via transcranial Doppler) were measured in 148 healthy adults (21-79 yr, 62% women). Cerebrovascular impedance was quantified using transfer function analysis. Coherence between changes in CBFV and CAP was >0.90 in the frequency range of 0.78-2.73 Hz, suggesting a linear dynamic relationship between these two variables. Impedance modulus at the first harmonics (0.78-1.56 Hz) of CBFV and CAP oscillations (Z
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.