Observational studyJournal of the American Geriatrics Society2021
The Prognostic Performance of Frailty for Delirium and Functional Decline in Vascular Surgery Patients.
Observational study in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The association between frailty and hospital-related adverse events in older hospitalised patients: a systematic literature review.European geriatric medicine · 2025Pooled it
- Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- Frailty score and outcomes of patients undergoing vascular surgery and amputation: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- Association between frailty and postoperative delirium: a meta-analysis of cohort study.Aging clinical and experimental research · 2022Pooled it
- Where Does It Hurt? A 4-S Model of Pain Onset and Recovery Across Body Sites Among Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Characteristics of older patients undergoing surgery in the UK: SNAP-3, a snapshot observational study.British journal of anaesthesia · 2025Observational
- Factors involved in the development of hospital-acquired conditions in older patients in acute care settings: a scoping review.BMC health services research · 2025Article
- Knowledge mapping of frailty and surgery: a bibliometric and visualized analysis.Langenbeck's archives of surgery · 2024Article
- Association of preoperative frailty with the risk of postoperative delirium in older patients undergoing hip fracture surgery: a prospective cohort study.Aging clinical and experimental research · 2024Article
- Article
- Optimising Medications in Older Vascular Surgery Patients Through Geriatric Co-management.Drugs & aging · 2023Article
- The influence of frailty on outcomes for older adults admitted to hospital with benign biliary disease: a single-centre, observational cohort study.Annals of the Royal College of Surgeons of England · 2023Observational
- Frail patients having vascular surgery during the early COVID-19 pandemic experienced high rates of adverse perioperative events and amputation.ANZ journal of surgery · 2022Article
- Incorporating Outcomes that Matter to Older Adults into Surgical Research.Journal of the American Geriatrics Society · 2021Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty in older vascular surgery patients is associated with increased mortality, hospital stay, and morbidity. The association of frailty with hospital-acquired geriatric syndromes such as delirium and functional decline has not been well studied.
objectivesTo investigate the association between frailty and hospital-acquired geriatric syndromes in older hospitalized vascular surgery patients, and to evaluate the prognostic performance of the frailty index (FI) and the Clinical Frailty Scale (CFS) for delirium and functional decline.
designProspective cohort study.
settingAcute care academic hospital.
participantsPatients aged 65 years or more admitted to a tertiary vascular surgery unit (N=150). MEASUREMENTS: Frailty was assessed using the FI and CFS. The adjusted association of frailty status with delirium and functional decline was assessed using logistic regression analysis. The prognostic performance of FI and CFS was determined by assessing C-statistic and positive and negative predictive values (PPV and NPV).
resultsOf 150 participants, FI identified 34 (23%) and CFS identified 45 (30%) as frail. Frailty was an independent predictor of delirium (FI adjusted odds ratio, odds ratio (OR) = 5.66, 95% confidence interval (CI) = 1.53-21.03; CFS adjusted OR = 4.07, 95% CI = 1.14-14.50), but not functional decline. FI and CFS showed acceptable prognostic performance for delirium (C-statistic 0.74), but not functional decline (C-statistic 0.63-0.64). For both outcomes, the FI and CFS had high NPV (86-96%), and low PPV (22-29%).
conclusionFrail older vascular surgery patients are more likely to develop hospital-acquired geriatric syndromes. The FI and CFS have acceptable prognostic performance for predicting delirium but not all individuals who are identified as frail develop delirium. Ongoing research is needed to identify interventions that improve outcomes in patients who screen positive for frailty.
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