Evidence map›Paper›PMID 33151463›Full record

ArticleMolecular and cellular biochemistry2021

Downregulation of lncRNA FIRRE relieved the neuropathic pain of female mice by suppressing HMGB1 expression.

Yuanyuan Wen, Xiaochong Fan, Huilian Bu, Letian Ma, Cunlong Kong, Chen Huang, Yuming Xu

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  3. The role of non-coding RNAs in neuropathic pain.Pflugers Archiv : European journal of physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuanyuan WenDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Xiaochong FanDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Huilian BuDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Letian MaDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Cunlong KongDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Chen HuangDepartment of Pain, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Yuming XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhongyuan District, Zhengzhou, 450000, China. buyurun14@163.com.ORCID http://orcid.org/0000-0002-9005-4728
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs are novel regulators in neuropathic pain. In this study, we aimed to explore the role and the mechanism of lncRNA FIRRE in regulating the secretion of microglial cells-derived proinflammatory cytokines in neuropathic pain. The female mouse model of neuropathic pain was established by bilateral chronic constriction injury (CCI) surgery. The mouse primary microglial cells were induced by lipopolysaccharide (LPS). The interaction between FIRRE and high mobility group box 1 (HMGB1) was assessed by RNA immunoprecipitation, RNA pull-down, and ubiquitination assays. FIRRE expression was upregulated in the spinal cord tissue of female CCI mice and LPS-induced microglial cells. The concentrations of IL-1β, TNF-α, and IL-6 from LPS-induced microglial cells were reduced by FIRRE knockdown. FIRRE bound to HMGB1 and negatively regulated its protein level. The ubiquitination degradation of HMGB1 was promoted by FIRRE silence. The HMGB1 over-expression reversed the inhibitory effect of FIRRE silence on the secretion of IL-1β, TNF-α, and IL-6 from LPS-induced microglial cells. The in vivo experiment showed that FIRRE knockdown alleviated neuropathic pain of CCI female mice. Our findings indicated that lncRNA FIRRE downregulation inhibits the secretion of microglial cells-derived proinflammatory cytokines by decreasing HMGB1 expression, thereby relieving neuropathic pain of female mice.

Indexed as

AnimalsCytokinesDisease Models, AnimalDown-RegulationFemaleHMGB1 ProteinMiceMice, Inbred C57BLMicrogliaNeuralgiaPrimary Cell CultureRNA, Long NoncodingCytokinesFirre long non coding RNA, mouseHMGB1 ProteinHMGB1 protein, mouseRNA, Long NoncodingHMGB1lncRNA FIRREMicroglial cellsNeuropathic painProinflammatory cytokines

Identifiers

PMID33151463
OpenAlexW3095591314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.