Evidence map›Paper›PMID 33151453›Full record

ArticleCell and tissue research2021

FGFR4 promotes nuclear localization of GABP to inhibit cell apoptosis in uterine leiomyosarcoma.

Pei Zhang, Hengliang Zhang, Yan Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pei ZhangDepartment of Gynaecology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, No. 24, Jinghua Road, Henan Province, 471000, Luoyang City, China. PeiZhangset@163.com.ORCID http://orcid.org/0000-0002-5216-335X
Hengliang ZhangDepartment of Cardiology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Henan Province, 471000, Luoyang City, China.
Yan WangDepartment of Gynaecology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, No. 24, Jinghua Road, Henan Province, 471000, Luoyang City, China.
First Affiliated Hospital of Henan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast growth factor receptor 4 (FGFR4) has been indicated as a potential "oncogene" in various types of cancer. However, the effects and underlying mechanisms of FGFR4 on uterine leiomyosarcoma (ULMS) progression remain unclear. In this study, we firstly discovered that FGFR4 was upregulated in ULMS specimens and cell lines and closely associated with poor prognosis of ULMS patients. Cell viability and apoptosis assays showed that FGFR4 deletion inhibited cell proliferation and promoted cell apoptosis. Moreover, FGFR4 silence increased cytoplasmic GABP (GA binding protein) expression, while it decreased the nuclear GABP level to inhibit nuclear localization of GABP. Mechanistically, the inhibition ability of FGFR4 silence on nuclear localization of GABP was mediated via mammalian Ste20-like kinases 1 (MST1) activation, which could promote phosphorylation of large tumor suppressor 1 (LATS1) to reduce nuclear localization of GABP. Gain- and loss-of-functional assays indicated that FGFR4 promoted nuclear localization of GABP to inhibit cell apoptosis in ULMS. In conclusion, our findings indicated that FGFR4 inhibited cell apoptosis in ULMS via the promotion of MST1/LATS1-mediated GABP nuclear localization, shedding light on the underlying mechanism of FGFR4-induced ULMS progression.

Indexed as

ApoptosisAdultAgedAged, 80 and overCell Line, TumorCell NucleusCell SurvivalFemaleGA-Binding Protein Transcription FactorGene Expression Regulation, NeoplasticHepatocyte Growth FactorHumansLeiomyosarcomaMiddle AgedModels, BiologicalPhosphorylationGA-Binding Protein Transcription FactorHepatocyte Growth FactorLATS1 protein, humanmacrophage stimulating proteinProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptor, Fibroblast Growth Factor, Type 4FGFR4GABPLATS1MST1Nuclear localizationUterine leiomyosarcoma

Identifiers

PMID33151453
OpenAlexW3096938847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.