ArticleJournal of the Association for Research in Otolaryngology : JARO2021
Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice.eNeuro · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cochlear Ribbon Synapses in Aged Gerbils.International journal of molecular sciences · 2024Article
- Damage-evoked signals in cochlear neurons and supporting cells.Frontiers in neurology · 2024Review
- Engineering olivocochlear inhibition to reduce acoustic trauma.Molecular therapy. Methods & clinical development · 2023Article
- Local Long-Term Inner Ear Drug Delivery in Normal Hearing Guinea Pig-An Animal Model to Develop Preventive Treatment for Noise-Induced Hearing Loss.Biomolecules · 2022Article
- Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice.Frontiers in neurology · 2022Article
- In Situ 3D-Imaging of the Inner Ear Synapses with a Cochlear Implant.Life (Basel, Switzerland) · 2021Article
- Quantitative FluorescentFrontiers in cellular neuroscience · 2021Article
- Article
- Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles.Frontiers in cell and developmental biology · 2021Article
- Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure.Frontiers in cell and developmental biology · 2021Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Outer hair cells (OHCs) in the mouse cochlea are contacted by up to three type II afferent boutons. On average, only half of these are postsynaptic to presynaptic ribbons. Mice of both sexes were subjected to acoustic trauma that produced a threshold shift of 44.2 ± 9.1 dB 7 days after exposure. Ribbon synapses of OHCs were quantified in post-trauma and littermate controls using immunolabeling of CtBP2. Visualization with virtual reality was used to determine 3-D cytoplasmic localization of CtBP2 puncta to the synaptic pole of OHCs. Acoustic trauma was associated with a statistically significant increase in the number of synaptic ribbons per OHC. Serial section TEM was carried out on similarly treated mice. This also showed a significant increase in the number of ribbons in post-trauma OHCs, as well as a significant increase in ribbon volume compared to ribbons in control OHCs. An increase in OHC ribbon synapses after acoustic trauma is a novel observation that has implications for OHC:type II afferent signaling. A mathematical model showed that the observed increase in OHC ribbons considered alone could produce a significant increase in action potentials among type II afferent neurons during strong acoustic stimulation.
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Registered trials
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