ArticlePsychopharmacology2021
Acute rewarding and disinhibiting effects of alcohol as indicators of drinking habits.
Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Cognitive preoccupation with drinking and behavioral effects of alcohol as predictors of current consumption patterns.Drug and alcohol dependence · 2023Trial
- Individual differences in ethanol drinking meal structure are shaped by social environments.bioRxiv : the preprint server for biology · 2026Article
- Self-underestimation of BAC as a predictor of risky driving in heavy drinkers.Drug and alcohol dependence · 2025Article
- Heightened motor impairment as a protective factor against heavy drinking in individuals with high alcohol-induced disinhibition.Alcohol, clinical & experimental research · 2023Article
- Cyp3A4 *1G polymorphism is associated with alcohol drinking: A 5-year retrospective single centered population-based study in China.PloS one · 2023Article
- Sensitivity to the disinhibiting effect of alcohol: The role of trait impulsivity and sex differences.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Assaultive trauma, alcohol use, and alcohol-related consequences among American Indian adolescents.Alcoholism, clinical and experimental research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleLaboratory studies have reliably shown that heightened sensitivity to the rewarding effects of alcohol is associated with heavier drinking patterns. More recently, there has been research to suggest that heightened sensitivity to the disinhibiting effects of alcohol might also contribute to drinking habits. Most research on the acute effects of alcohol has focused on drinking magnitudes averaged across participants with little attention paid to how individual differences influence alcohol abuse potential. In large part, this is due to limited sample sizes in previous laboratory studies.
objectivesThis study overcomes previous limitations by testing the degree to which individual differences in acute sensitivity and tolerance to the rewarding and disinhibiting effects of alcohol relate to drinking behavior in a large sample size.
methodsData from six laboratory studies were aggregated to comprise a sample of 181 adults. Participants' level of "liking" (the effects of alcohol) and disinhibition were assessed following 0.65 g/kg alcohol once during the ascending limb of the blood alcohol concentration (BAC) curve and again at the same BAC during the descending limb of the curve. The measures were also assessed following placebo.
resultsAlcohol increased ratings of liking and behavioral disinhibition. Heavier drinking was associated with heightened sensitivity to liking on the ascending limb. Additionally, those who showed reduced acute tolerance to both disinhibition and liking were also heavier drinkers.
conclusionsThese data suggest that individual variability in liking the effects of alcohol and persistent disinhibition are key indicators of drinking habits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.