Evidence map›Paper›PMID 33151300›Full record

ArticleThe Journal of infectious diseases2021

Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men.

Deepti Bettampadi, Brittney Dickey, Martha Abrahamsen, Bradley Sirak, Maria Luiza Baggio, Lenice Galan, Roberto Carvalho Silva, Luisa Villa, Eduardo Lazcano Ponce, Anna R Giuliano

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Deepti BettampadiCenter for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Brittney DickeyCenter for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Martha AbrahamsenCenter for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Bradley SirakCenter for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Maria Luiza BaggioInstituto do Cancer do Estado de São Paulo, São Paulo, Brazil.
Lenice GalanCentro de Referencia e Treinamento em DST/AIDS, São Paulo, Brazil.
Roberto Carvalho SilvaCentro de Referencia e Treinamento em DST/AIDS, São Paulo, Brazil.
Luisa VillaInstituto do Cancer do Estado de São Paulo, São Paulo, Brazil.
Eduardo Lazcano PonceCenter for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Anna R GiulianoCenter for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Moffitt Cancer Center · USInstituto do Câncer do Estado de São Paulo · BRInstituto Nacional de Salud Pública · MX

Funding

Investigation of Oral HPV Infection Natural History and Biomarkers of Persistent Infection: The HIM StudyR01CA214588 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GIULIANO, ANNA R. · 2017 to 2021
$3.6M
Moffitt Postdoctoral Training Program in Molecular EpidemiologyT32CA147832 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KANETSKY, PETER A · 2015 to 2019
$659k
NCI NIH HHS R01 CA214588NCI NIH HHS T32 CA147832
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately.

methodsOral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence.

resultsThe prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22-2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15-2.40) and smoking (1.66; 95% CI, 1.13-2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35-3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints.

conclusionsDifferent factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.

Indexed as

AlphapapillomavirusOropharyngeal NeoplasmsPapillomavirus InfectionsGenotypeHumansMaleMexicoOral HealthPrevalenceRisk FactorsSexual BehaviorHPVinternationalmenoralrisk factor

Identifiers

PMID33151300
PMCPMC8205625
OpenAlexW3095592650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.