Evidence map›Paper›PMID 33151278›Full record

ArticleThe international journal of neuropsychopharmacology2021

Dopamine D2/3 Receptor Availabilities and Evoked Dopamine Release in Striatum Differentially Predict Impulsivity and Novelty Preference in Roman High- and Low-Avoidance Rats.

Lidia Bellés, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, François R Herrmann, Nathalie Ginovart

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  9. Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023
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  12. A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lidia BellésDepartment of Psychiatry, University of Geneva, Switzerland.
Andrea DimizianiDepartment of Psychiatry, University of Geneva, Switzerland.
Stergios TsartsalisFaculty of Medicine, University of Geneva, Switzerland.
Philippe MilletDepartment of Psychiatry, University of Geneva, Switzerland.
François R HerrmannDivision of Geriatrics, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Switzerland.
Nathalie GinovartDepartment of Psychiatry, University of Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpulsivity and novelty preference are both associated with an increased propensity to develop addiction-like behaviors, but their relationship and respective underlying dopamine (DA) underpinnings are not fully elucidated.

methodsWe evaluated a large cohort (n = 49) of Roman high- and low-avoidance rats using single photon emission computed tomography to concurrently measure in vivo striatal D2/3 receptor (D2/3R) availability and amphetamine (AMPH)-induced DA release in relation to impulsivity and novelty preference using a within-subject design. To further examine the DA-dependent processes related to these traits, midbrain D2/3-autoreceptor levels were measured using ex vivo autoradiography in the same animals.

resultsWe replicated a robust inverse relationship between impulsivity, as measured with the 5-choice serial reaction time task, and D2/3R availability in ventral striatum and extended this relationship to D2/3R levels measured in dorsal striatum. Novelty preference was positively related to impulsivity and showed inverse associations with D2/3R availability in dorsal striatum and ventral striatum. A high magnitude of AMPH-induced DA release in striatum predicted both impulsivity and novelty preference, perhaps owing to the diminished midbrain D2/3-autoreceptor availability measured in high-impulsive/novelty-preferring Roman high-avoidance animals that may amplify AMPH effect on DA transmission. Mediation analyses revealed that while D2/3R availability and AMPH-induced DA release in striatum are both significant predictors of impulsivity, the effect of striatal D2/3R availability on novelty preference is fully mediated by evoked striatal DA release.

conclusionsImpulsivity and novelty preference are related but mediated by overlapping, yet dissociable, DA-dependent mechanisms in striatum that may interact to promote the emergence of an addiction-prone phenotype.

Indexed as

AmphetamineAnimalsAutoreceptorsBehavior, AnimalDopamineDopamine AgentsExploratory BehaviorImpulsive BehaviorMaleNeostriatumRatsReceptors, Dopamine D2Receptors, Dopamine D3Tomography, Emission-Computed, Single-PhotonVentral StriatumAmphetamineAutoreceptorsDopamineDopamine AgentsDRD2 protein, ratDrd3 protein, ratReceptors, Dopamine D2Receptors, Dopamine D3D2/3 receptorsDopamineimpulsivitynovelty preference

Identifiers

PMID33151278
PMCPMC7968620
OpenAlexW3094820551

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.