Evidence map›Paper›PMID 33151137›Full record

ArticleUnited European gastroenterology journal2021

A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group.

Josbert J Keller, Rogier E Ooijevaar, Christian L Hvas, Elisabeth M Terveer, Simone C Lieberknecht, Christoph Högenauer, Perttu Arkkila, Harry Sokol, Oleksiy Gridnyev, Francis Mégraud and 30 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Transient colonization with Blastocystis spp. after transmission via fecal microbiota transplantation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Trial
  6. Trial
  7. Fecal Microbiota Transplantation BeyondJournal of Korean medical science · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Josbert J KellerDepartment of Gastroenterology, Haaglanden Medical Center, The Hague, The Netherlands.
Rogier E OoijevaarNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Christian L HvasDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Elisabeth M TerveerNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Simone C LieberknechtDepartment of Internal Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany.
Christoph HögenauerDivision of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
Perttu ArkkilaDepartment of Gastroenterology, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Harry SokolGastroenterology Department, Saint Antoine Hospital, Paris, France.ORCID 0000-0002-2914-1822
Oleksiy GridnyevL.T. Malaya Therapy, National Institute of the National Academy of Medical Sciences of Ukraine,  Kyiv, Ukraine.
Francis MégraudINSERM U1053, University of Bordeaux and Bacteriology Laboratory, Pellegrin Hospital, Bordeaux, France.
Patrizia K KumpDivision of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
Radislav NakovClinic of Gastroenterology, Tsaritsa Yoanna University Hospital, Sofia, Bulgaria.
Simon D GoldenbergCentre for Clinical Infection and Diagnostics Research (CIDR), King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK.
Reetta SatokariHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4258-3414
Sergiy TkatchUkranian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and TissuesA, Kyiv, Ukraine.
Maurizio SanguinettiDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Giovanni CammarotaGastroenterology Area, Fondazione Policlinico Universitario Gemelli, Rome, Italy.
Andrey DorofeevDepartment of Internal Medicine, National Medical Academy of Postgraduate Education n.a. P.L. Shupic, Kiev, Ukraine.
Olena GubskaDepartment of Therapy, Infectious Diseases and Dermatology Postgraduate Education, Bogomolets National Medical University, Kyiv, Ukraine.
Gianluca IaniroGastroenterology Area, Fondazione Policlinico Universitario Gemelli, Rome, Italy.
Eero MattilaHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ramesh P ArasaradnamDepartment of Academic Gastroenterology, University Hospital Coventry and Warwick, Coventry, UK.ORCID 0000-0002-2231-3062
Shiv K SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Ajit SoodDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.
Lorenza PutignaniDepartment of Laboratories, Bambino Gesù Children's Hospital, Rome, Italy.
Laurent AlricDepartment of Internal Medicine and Digestive Diseases, IRD Toulouse 3 University, Toulouse, France.
Simon M D BaunwallDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-5135-7435
Juozas KupcinskasDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Alexander LinkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
Abraham G GoorhuisDepartment of Internal Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Hein W VerspagetNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Cyriel PonsioenDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Georgina L HoldMicrobiome Research Centre, St. George and Sutherland Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Herbert TilgDepartment of Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.
Zain KassamFinch Therapeutics, Somerville, Massachusetts, USA.
Ed J KuijperNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Antonio GasbarriniGastroenterology Area, Fondazione Policlinico Universitario Gemelli, Rome, Italy.
Chris J J MulderNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Horace R T WilliamsFaculty of Medicine, Imperial College London, London, UK.
Maria J G T VehreschildDepartment of Internal Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany.

Funding

Department of Health PB-PG-0418-20007
6 · The paper itself

Abstract

backgroundFaecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of faeces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council.

objectiveSeveral European and international consensus statements concerning faecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document.

methodsCollaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about faecal microbiota transplantation.

resultsA guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening.

conclusionThe implementation of faecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor faeces preparations for patients.

Indexed as

Fecal Microbiota TransplantationFecesAge FactorsBiological Specimen BanksClostridioides difficileClostridium InfectionsContraindications, ProcedureDonor SelectionHumansImmunocompromised HostInformed ConsentQuality Assurance, Health CareRecurrenceSpecimen HandlingClostridioides difficilefaecal microbiota transplantationlegislationstool bank

Identifiers

PMID33151137
PMCPMC8259288

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.