ArticleHuman brain mapping2021
Emotion processing and regulation in major depressive disorder: A 7T resting-state fMRI study.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Is cardiac autonomic control affected in major depressive disorder? A systematic review of heart rate variability studies.Translational psychiatry · 2025Pooled it
- The effectiveness of non-invasive brain stimulation in treatment of major depressive disorder (MDD): a systematic review and transfer analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2025Pooled it
- Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis.Molecular psychiatry · 2025Pooled it
- In search of convergent regional brain abnormality in cognitive emotion regulation: A transdiagnostic neuroimaging meta-analysis.Human brain mapping · 2022Pooled it
- Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis.Brain imaging and behavior · 2022Pooled it
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study.JMIR mental health · 2026Observational
- Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.Depression and anxiety · 2026Article
- Depression links to unstable resting-state brain dynamics: insights from hidden markov models and functional network variability.Psychological medicine · 2025Article
- Maternal depression during the perinatal period and its relationship with emotion regulation in young adulthood: An fMRI study in a prenatal birth cohort.Psychological medicine · 2025Article
- Assessment of Resting-state functional Magnetic Resonance Imaging Connectivity Among Patients with Major Depressive Disorder: A Comparative Study.Annals of neurosciences · 2025Article
- Semantic fMRI neurofeedback of emotions: from basic principles to clinical applications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The Clinical Impact of Real-Time fMRI Neurofeedback on Emotion Regulation: A Systematic Review.Brain sciences · 2024Review
- Improved clinical outcome prediction in depression using neurodynamics in an emotional face-matching functional MRI task.Frontiers in psychiatry · 2024Article
- Activation Likelihood Estimation Neuroimaging Meta-Analysis: a Powerful Tool for Emotion Research.Psychology research and behavior management · 2024Review
- Associations between capacity of cognitive control and sleep quality: a two-wave longitudinal study.Frontiers in psychology · 2024Article
- Functional near-infrared spectroscopy neurofeedback of dorsolateral prefrontal cortex enhances human spatial working memory.Neurophotonics · 2023Article
- Altered Functional Connectivity and Complexity in Major Depressive Disorder after Musical Stimulation.Brain sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysfunctions in bottom-up emotion processing (EP), as well as top-down emotion regulation (ER) are prominent features in pathophysiology of major depressive disorder (MDD). Nonetheless, it is not clear whether EP- and ER-related areas are regionally and/or connectively disturbed in MDD. In addition, it is yet to be known how EP- and ER-related areas are interactively linked to regulatory behavior, and whether this interaction is disrupted in MDD. In our study, regional amplitude of low frequency fluctuations (ALFF) and whole-brain functional connectivity (FC) of meta-analytic-driven EP- and ER-related areas were compared between 32 healthy controls (HC) and 20 MDD patients. Then, we aimed to investigate whether the EP-related areas can predict the ER-related areas and regulatory behavior in both groups. Finally, the brain-behavior correlations between the EP- and ER-related areas and depression severity were assessed. We found that: (a) affective areas are regionally and/or connectively disturbed in MDD; (b) EP-ER interaction seems to be disrupted in MDD; overburden of emotional reactivity in amygdala may inversely affect cognitive control processes in prefrontal cortices, which leads to diminished regulatory actions. (c) Depression severity is correlated with FC of affective areas. Our findings shed new lights on the neural underpinning of affective dysfunctions in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.