ArticleMagnetic resonance in medicine2021
Combining chemical exchange saturation transfer and
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- MR Spectroscopy Without Water Suppression Using the Gradient Impulse Response Function.Magnetic resonance in medicine · 2026Article
- Effect of Water Suppression and Metabolite Cycling on Quantification ofMagnetic resonance in medicine · 2026Article
- Downfield magnetic resonance signals serve as endogenous imaging biomarkers of nucleotide metabolism in glioma.Communications biology · 2026Article
- Toward quantitative CEST imaging of glutamate in the mouse brain using a multi-pool exchange model calibrated byMagnetic resonance in medicine · 2025Article
- High-field downfield MR spectroscopic imaging in the human brain.Magnetic resonance in medicine · 2024Article
- Estimating the synaptic density deficit in Alzheimer's disease using multi-contrast CEST imaging.PloS one · 2024Article
- Downfield proton MRSI with whole-brain coverage at 3T.Magnetic resonance in medicine · 2023Article
- Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors.NMR in biomedicine · 2023Article
- Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T.Magnetic resonance in medicine · 2022Article
- Advanced Imaging Techniques for Newly Diagnosed and Recurrent Gliomas.Frontiers in neuroscience · 2022Review
- Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo.Current opinion in chemical biology · 2021Review
- Combining chemical exchange saturation transfer andMagnetic resonance in medicine · 2021Article
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Authors and funding
4 authors.
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Abstract
purposeA new sequence combining chemical-exchange saturation-transfer (CEST) with traditional MRS is used to simultaneously determine metabolite content and effects of magnetization exchange.
methodsA CEST saturation block consisting of a train of RF-pulses is placed before a metabolite-cycled semi-LASER single-voxel spectroscopy sequence. The saturation parameters are adjustable to allow optimization of the saturation for a specific target. Data were collected in brain from 20 subjects in experiments with different B
resultsEvaluation of traditional Z-spectra from water revealed exchange effects from amides, amines, and hydroxyls as well as an upfield nuclear Overhauser effect. The magnetization transfer effect was evaluated on metabolites and macromolecules for the whole spectral range and for the different B
conclusionUsing non-water-suppressed spectroscopy offers time-saving simultaneous recording of the traditional CEST Z-spectrum from water and the metabolite spectrum under frequency-selective saturation. In addition, exchange and magnetization-transfer effects on metabolites and macromolecules can be detected, which might offer additional possibilities for quantification or give further insight into the composition of the traditional CEST Z-spectrum. Apparent magnetization-transfer effects on macromolecular signals in the
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