ArticleSocial cognitive and affective neuroscience2020
Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.
Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effects and safety of repetitive transcranial magnetic stimulation on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- The selective dynamics of proactive and reactive control in GAD: A taVNS study using hierarchical drift diffusion modeling.Cognitive, affective & behavioral neuroscience · 2026Article
- Histamine shapes the neurocomputational dynamics of human learning.Nature communications · 2026Article
- The Philadelphia Theta Burst Project: A novel fMRI-guided electric field modeling dataset with reliability metrics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Potential neurophysiological mechanisms of intermittent theta-burst stimulation to the left prefrontal cortex for post-stroke unilateral neglect: An exploratory transcranial magnetic stimulation - electroencephalography study.IBRO neuroscience reports · 2025Article
- Role of the Locus Coeruleus in Response to Threat in Anxiety Disorders and Posttraumatic Stress Disorder: An Ultra-High-Field 7T Functional Magnetic Resonance Imaging Study.Biological psychiatry global open science · 2025Article
- Effects of tDCS of the DLPFC on brain networks: A hybrid brain modeling study.PLoS computational biology · 2025Article
- Correlations between depressive symptoms, verbal working memory, and physical activity in university students: evidence based on resting EEG.BMC psychiatry · 2025Article
- Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder.Depression and anxiety · 2025Article
- Article
- Research progress on the neural circuits mechanisms of anxiety.Frontiers in neural circuits · 2025Review
- The maintenance of complex visual scenes in working memory may require activation of working memory manipulation circuits in the dlPFC: a preliminary report.Mental health science · 2024Article
- Threat of shock increases distractor susceptibility during the short-term maintenance of visual information.Social cognitive and affective neuroscience · 2024Article
- Interleaved TMS/fMRI shows that threat decreases dlPFC-mediated top-down regulation of emotion processing.NPP - digital psychiatry and neuroscience · 2024Article
- Right-lateralized sleep spindles are associated with neutral over emotional bias in picture recognition: An overnight study.Cognitive, affective & behavioral neuroscience · 2023Article
- Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.Biological psychiatry global open science · 2023Article
- Avoidance-motivational intensity modulated the effect of negative emotion on working memory.Royal Society open science · 2023Article
- Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples.Molecular psychiatry · 2023Article
- The role of dlPFC laterality in the expression and regulation of anxiety.Neuropharmacology · 2023Review
- Recognition memory, primacy vs. recency effects, and time perception in the online version of the fear of scream paradigm.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
One of the hallmarks of anxiety disorders is impaired cognitive control, affecting working memory (WM). The dorsolateral prefrontal cortex (dlPFC) is critical for WM; however, it is still unclear how dlPFC activity relates to WM impairments in patients. Forty-one healthy volunteers and 32 anxiety (general and/or social anxiety disorder) patients completed the Sternberg WM paradigm during safety and unpredictable shock threat. On each trial, a series of letters was presented, followed by brief retention and response intervals. On low- and high-load trials, subjects retained the series (five and eight letters, respectively) in the original order, while on sort trials, subjects rearranged the series (five letters) in alphabetical order. We sampled the blood oxygenation level-dependent activity during retention using a bilateral anatomical dlPFC mask. Compared to controls, patients showed increased reaction time during high-load trials, greater right dlPFC activity and reduced dlPFC activity during threat. These results suggest that WM performance for patients and controls may rely on distinct patterns of dlPFC activity with patients requiring bilateral dlPFC activity. These results are consistent with reduced efficiency of WM in anxiety patients. This reduced efficiency may be due to an inefficient allocation of dlPFC resources across hemispheres or a decreased overall dlPFC capacity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.