ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2021
Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Disulfiram-ethanol Reaction Linked to the Consumption of Fermented Pickles: A Unique Case Encounter.Indian journal of psychological medicine · 2025Article
- Clinician Prescribing Practices Involving Medications for Alcohol Use Disorder.American journal of preventive medicine · 2025Article
- Acute Ethanol-Disulfiram Reaction Presenting With Hemodynamic Instability: A Case Report.Cureus · 2025Article
- Safety assessment of disulfiram: real-world adverse event analysis based on FAERS database.Frontiers in psychiatry · 2024Article
- Hand Sanitizer Gels: Classification, Challenges, and the Future of Multipurpose Hand Hygiene Products.Toxics · 2023Review
- Disulfiram: Mechanisms, Applications, and Challenges.Antibiotics (Basel, Switzerland) · 2023Review
- Disulfiram-Mitigating Unintended Effects.Antibiotics (Basel, Switzerland) · 2023Review
- Sensitivity of SARS-CoV-2 towards Alcohols: Potential for Alcohol-Related Toxicity in Humans.Life (Basel, Switzerland) · 2021Review
- Effects of the COVID-19 pandemic and lockdown on alcohol use disorders and complications.Current opinion in psychiatry · 2021Review
- Alcohol-Based Hand Sanitizers in COVID-19 Prevention: A Multidimensional Perspective.Pharmacy (Basel, Switzerland) · 2021Review
- Disulfiram-like reaction with ornidazole: A case report of a rare interaction.Turkish journal of emergency medicineArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe conducted a cross-sectional survey to estimate the prevalence and clinical manifestation of disulfiram ethanol reaction (DER) and isopropanol toxicity (IT) in patients with alcohol use disorders, on disulfiram. Alcohol-based hand rub contains either ethanol or isopropanol or both. COVID-19 pandemic has led to wide scale usage of sanitizers. Patients with alcohol use disorders, on disulfiram, might experience disulfiram ethanol like reactions with alcohol-based sanitizers.
methodsWe telephonically contacted 339 patients, prescribed disulfiram between January 2014 and March 2020. The assessment pertained to the last 3 months (i.e. third week of March to third week of June 2020).
resultThe sample consisted of middle-aged men with a mean 16 years of alcohol dependence. Among the 82 (24%) patients adherent to disulfiram, 42 (12.3%) were using alcohol-based hand rubs. Out of these, a total of eight patients (19%; 95% CI 9-33) had features suggestive of DER; four of whom also had features indicative of IT. Five patients (62.5%) had mild and self-limiting symptoms. Severe systemic reactions were experienced by three (37.5%). Severe reactions were observed with exposure to sanitizers in greater amounts, on moist skin or through inhalation.
conclusionPatients on disulfiram should be advised to use alternate methods of hand hygiene.
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Registered trials
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