ArticleJournal of biomedical optics2020
Exploring the feasibility of wavelength modulated near-infrared spectroscopy.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Simultaneous estimation of absolute concentrations of chromophores and the differential pathlength factor in forearm muscle using spectral derivatives.Biomedical optics express · 2026Article
- Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model.Biomedical optics express · 2024Article
- Using spectral derivatives to remove the influence of hair on optical images of the static absorbing properties of tissue-like turbid media.Neurophotonics · 2024Article
- Design for a low-cost heterodyne frequency domain-diffuse optical spectroscopy system.Biomedical optics express · 2023Article
- Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter.Optica · 2023Article
- Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination.Journal of biomedical optics · 2022Article
- Beer-Lambert law for optical tissue diagnostics: current state of the art and the main limitations.Journal of biomedical optics · 2021Review
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Authors and funding
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Abstract
significanceThe application of near-infrared spectroscopy (NIRS) to determine the concentrations of tissue chromophores has typically relied on three alternative technological approaches: continuous-wave, frequency-domain, and time-domain. It is often the case that uncertain and variable coupling of light into and out of the skin surface renders absolute measurements unreliable, and NIRS methods are mostly used to measure changes of chromophore concentrations and of physiological parameters such as blood volume and oxygenation.
aimThe aim has been to investigate whether an approach based on a wavelength-modulated source may enable measurements to be acquired, which are independent of surface coupling and may facilitate derivation of absolute values of tissue parameters. APPROACH: An analysis is performed using the modified Beer-Lambert law.
resultsIt is shown that the relative modulation in detected intensity resulting from a wavelength-modulated source could be used to estimate absolute concentrations of chromophores if unknown surface coupling losses and geometrical factors are insensitive to small changes in wavelength.
conclusionsWavelength modulated NIRS could be an effective tool for quantitative in vivo analysis of tissues, although it may be technically challenging.
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