Evidence map›Paper›PMID 33150745›Full record

Trial reportObesity (Silver Spring, Md.)2020

A Randomized Controlled Trial of Ovarian Suppression in Premenopausal Women: No Change in Free-Living Energy Expenditure.

Kathleen M Gavin, Edward L Melanson, Kerry L Hildreth, Ellie Gibbons, Daniel H Bessesen, Wendy M Kohrt

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure.The Journal of clinical endocrinology and metabolism · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kathleen M GavinDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-4102-8424
Edward L MelansonDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-9151-9745
Kerry L HildrethDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ellie GibbonsDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Daniel H BessesenDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Wendy M KohrtDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Geriatric Research Education and Clinical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2018 to 2026
$13.5M
Sex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7M
Sex differences in adipogenic potential of adipose tissue myeloid cells in humansK01DK109053 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GAVIN, KATHLEEN MARIE · 2016 to 2020
$724k
NCATS NIH HHS UL1 TR002535NIA NIH HHS U54 AG062319NICHD NIH HHS P50 HD073063NIDDK NIH HHS K01 DK109053NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine whether suppression of ovarian function (gonadotropin-releasing hormone agonist [GnRH

methodsPremenopausal women who were approaching menopause (mean [SD]: age 46 [3] years, BMI 26.3 [4.8] kg/m

resultsChanges in TDEE, PAEE, REE, or body composition were not different between groups. However, within the GnRH

conclusionsIn premenopausal women approaching menopause, ovarian hormone suppression resulted in increased adiposity without alterations in TDEE, PAEE, or REE.

Indexed as

Energy MetabolismFemaleHumansMiddle AgedOvaryPremenopause

Identifiers

PMID33150745
PMCPMC7653843
OpenAlexW3095618605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.