ArticleJournal of the Association for Research in Otolaryngology : JARO2021
Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Effect of Taking a Break From Cochlear-Implant Use for Resolving Facial-Nerve Stimulation: A Case Series.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- Threshold-distance functions predict speech recognition with cochlear implants.Scientific reports · 2025Article
- An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Polarity sensitivity to symmetric, biphasic monopolar pulses is not a reliable indicator of peripheral axonal degeneration in human cochlear implant users.Frontiers in audiology and otology · 2025Article
- Effects of selective stimulation of apical electrodes on temporal pitch perception by cochlear implant recipients.The Journal of the Acoustical Society of America · 2024Article
- Electric Auditory Brainstem Response Audiometry in Cochlear Implants: New Recording Paradigm.Audiology research · 2024Article
- Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.medRxiv : the preprint server for health sciences · 2024Article
- Electrically evoked compound action potential polarity sensitivity, refractory-recovery, and behavioral multi-pulse integration as potential indices of neural health in cochlear-implant recipients.Hearing research · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Electrical Field Interactions during Adjacent Electrode Stimulations: eABR Evaluation in Cochlear Implant Users.Journal of clinical medicine · 2023Article
- Electrically evoked compound action potentials in cochlear implant users with preoperative residual hearing.Frontiers in human neuroscience · 2023Article
- Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.Hearing research · 2022Review
- Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Assessing the Relationship Between Pitch Perception and Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Characterizing Polarity Sensitivity in Cochlear Implant Recipients: Demographic Effects and Potential Implications for Estimating Neural Health.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Variations in neural health along the cochlea can degrade the spectral and temporal representation of sounds conveyed by cochlear implants (CIs). We evaluated and compared one electrophysiological measure and two behavioural measures that have been proposed as estimates of neural health patterns, in order to explore the extent to which the different measures provide converging and consistent neural health estimates. All measures were obtained from the same 11 users of the Cochlear Corporation CI. The two behavioural measures were multipulse integration (MPI) and the polarity effect (PE), both measured on each of seven electrodes per subject. MPI was measured as the difference between thresholds at 80 pps and 1000 pps, and PE as the difference in thresholds between cathodic- and anodic-centred quadraphasic (QP) 80-pps pulse trains. It has been proposed that good neural health corresponds to a large MPI and to a large negative PE (lower thresholds for cathodic than anodic pulses). The electrophysiological measure was the effect of interphase gap (IPG) on the offset of the ECAP amplitude growth function (AGF), which has been correlated with spiral ganglion neuron density in guinea pigs. This 'IPG offset' was obtained on the same subset of electrodes used for the behavioural measures. Despite high test-retest reliability, there were no significant correlations between the neural health estimates for either within-subject comparisons across the electrode array, or between-subject comparisons of the means. A phenomenological model of a population of spiral ganglion neurons was then used to investigate physiological mechanisms that might underlie the different neural health estimates. The combined experimental and modelling results provide evidence that PE, MPI and IPG offset may reflect different characteristics of the electrode-neural interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.