Evidence map›Paper›PMID 33150535›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population.

Hirofumi Matsumoto, Reika Takamatsu, Norie Abe, Mikiko Unesoko, Hisamitsu Zaha, Akiko Ishii, Norihiro Nakada, Hiroshi Nishihara, Puay Hoon Tan, Naoki Yoshimi

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Spiradenoma: A Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Hirofumi MatsumotoDepartment of Pathology, Nakagami Hospital, Noborikawa, Okinawa City, Okinawa, 904-2195, Japan. matsumoto@nakagami.or.jp.ORCID http://orcid.org/0000-0003-4216-8939
Reika TakamatsuGenomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.
Norie AbeDepartment of Breast Surgery, Nakagami Hospital, Okinawa, Japan.
Mikiko UnesokoDepartment of Breast Surgery, Nakagami Hospital, Okinawa, Japan.
Hisamitsu ZahaDepartment of Breast Surgery, Nakagami Hospital, Okinawa, Japan.
Akiko IshiiDepartment of Pathology, Nakagami Hospital, Noborikawa, Okinawa City, Okinawa, 904-2195, Japan.
Norihiro NakadaDepartment of Pathology, Nakagami Hospital, Noborikawa, Okinawa City, Okinawa, 904-2195, Japan.
Hiroshi NishiharaGenomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.
Puay Hoon TanDivision of Pathology, Singapore General Hospital, Singapore, Singapore.
Naoki YoshimiDepartment of Pathology, Japanese Red Cross Okinawa Hospital, Okinawa, Japan.
Keio University · JPOkinawa Prefectural Chubu Hospital · JPOkinawa Prefecture · JPOkinawa Red Cross Hospital · JPSingapore General Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast spiradenoma is extremely rare, with only 4 cases reported previously. We describe an instructive case of breast spiradenoma resembling adenoid cystic carcinoma (AdCC). A 71-year-old woman underwent excisional biopsy of a breast mass after a conclusive diagnosis was unable to be obtained from core needle biopsy showing an AdCC-like pattern. Histopathologically, the lesion demonstrated solid and cribriform foci comprising basaloid cells, luminal cells, and eosinophilic hyaline material, reminiscent of solid-basaloid AdCC, alongside convoluted lumens, stromal edema, lymphocytic infiltration, and c-kit negativity. On molecular analysis, neither MYB fusion genes nor CYLD gene abnormalities were identified. These results were supportive of spiradenoma. Salivary gland- and skin adnexal-type tumors are challenging to diagnose due to morphological overlaps. This case, highlighting histopathological and molecular features, shows that breast spiradenoma can be a diagnostic pitfall among the differential diagnoses of AdCC.

Indexed as

AcrospiromaAgedBiomarkers, TumorBiopsyBreast NeoplasmsCarcinoma, Adenoid CysticDiagnosis, DifferentialFemaleHumansImmunohistochemistryMolecular Diagnostic TechniquesPredictive Value of TestsSweat Gland NeoplasmsTreatment OutcomeBiomarkers, TumorAdenoid cystic carcinomaBreast tumorSkin adnexal–type neoplasmsSpiradenoma

Identifiers

PMID33150535
OpenAlexW3096794360

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.