ReviewEating and weight disorders : EWD2021
Liver disease in obesity and underweight: the two sides of the coin. A narrative review.
Review in Eating and weight disorders : EWD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: A double-blind, cross-over, randomised controlled trial.Diabetes/metabolism research and reviews · 2022Trial
- Monitoring with plasma apolipoprotein A2-isoforms can predict developing new-onset steatotic liver disease caused by pancreatic exocrine insufficiency following pancreatectomy.Hepatobiliary surgery and nutrition · 2026Article
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction.Cell reports · 2025Article
- Clinical Outcomes in Acute Decompensated Metabolic Dysfunction-associated Steatotic Liver Disease Cirrhosis: The Role of BMI in Mortality, Readmission, and Hospital Stay.Journal of general internal medicine · 2025Article
- Shape of You: Eye-Tracking and Social Perceptions of the Human Body.Behavioral sciences (Basel, Switzerland) · 2025Article
- Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study.Eating and weight disorders : EWD · 2025Observational
- Hypogonadism and nonalcoholic fatty liver disease.Endocrine · 2024Review
- Hepatic mitochondrial and peroxisomal alterations in acutely ill malnourished Malawian children: A postmortem cohort study.Global pediatrics · 2024Article
- Article
- Emergency room presentations of people with anorexia nervosa.Journal of eating disorders · 2023Review
- Metabolic reprogramming of hepatocytes byJHEP reports : innovation in hepatology · 2023Article
- Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet.Frontiers in nutrition · 2023Article
- Observational
- Association between the atherogenic index of plasma and new-onset non-alcoholic fatty liver disease in non-obese participants.Frontiers in endocrinology · 2022Article
- Managing abnormal liver tests in children with inflammatory bowel disease.Current opinion in pediatrics · 2021Review
- The psychological impact of COVID-19 pandemic on patients included in a bariatric surgery program.Eating and weight disorders : EWD · 2021Article
- The utility of assessing C-peptide in patients with insulin-treated type 2 diabetes: a cross-sectional study.Acta diabetologica · 2021Article
- Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population.Scientific reports · 2021Article
- Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review.Nutrients · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMalnutrition, whether characterized by not enough or too much nutrient intake, is detrimental to the liver. We herein provide a narrative literature revision relative to hepatic disease occurrence in over or undernourished subjects, to shed light on the paradox where both sides of malnutrition lead to similar liver dysfunction and fat accumulation.
methodsMedline, EMBASE, and Cochrane Library were searched for publications up to July 2020. Articles discussing the association between both chronic and acute liver pathology and malnutrition were evaluated together with studies reporting the dietary intake in subjects affected by malnutrition.
resultsThe association between overnutrition and non-alcoholic fatty liver disease (NAFLD) is well recognized, as the beneficial effects of calorie restriction and very low carbohydrate diets. Conversely, the link between undernutrition and liver injury is more complex and less understood. In developing countries, early exposure to nutrient deficiency leads to marasmus and kwashiorkor, accompanied by fatty liver, whereas in developed countries anorexia nervosa is a more common form of undernutrition, associated with liver injury. Weight gain in undernutrition is associated with liver function improvement, whereas no study on the impact of macronutrient distribution is available. We hypothesized a role for very low carbohydrate diets in the management of undernutrition derived liver pathology, in addition to the established one in overnutrition-related NAFLD.
conclusionsFurther studies are warranted to update the knowledge regarding undernutrition-related liver disease, and a specific interest should be paid to macronutrient distribution both in the context of refeeding and relative to its role in the development of hepatic complications of anorexia nervosa. LEVEL OF EVIDENCE: Narrative review, Level V.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.