Evidence map›Paper›PMID 33150506›Full record

ArticleEnvironmental science and pollution research international2021

Nephroprotective effect of ethanol extract and fractions of a sea lettuce, Ulva fasciata against cisplatin-induced kidney injury in rats.

Nida Sohail, Khan Hira, Junaid Ahmed Kori, Hafiza Farhat, Faizah Urooj, Waqas Khan, Viqar Sultana, Muhammad Shaiq Ali, Syed Ehteshamul-Haque

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Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nida SohailDepartment of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.
Khan HiraInstitute of Biomedical Sciences, Dow University of Health Sciences, Karachi, 75270, Pakistan.
Junaid Ahmed KoriUS-Pakistan Center for Advanced Studies in Water, Mehran University of Engineering and Technology, Jamshoro, 76062, Pakistan.
Hafiza FarhatDepartment of Botany, University of Karachi, Karachi, 75270, Pakistan.
Faizah UroojDepartment of Botany, University of Karachi, Karachi, 75270, Pakistan.
Waqas KhanEuronano Diagnostics-Anatolia Geneworks, 225/1, PECHS, Block-2, Karachi, Pakistan.
Viqar SultanaDepartment of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.
Muhammad Shaiq AliH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Syed Ehteshamul-HaqueDepartment of Botany, University of Karachi, Karachi, 75270, Pakistan. sehaq@uok.edu.pk.
University of Karachi · PKDow University of Health Sciences · PKMehran University of Engineering and Technology · PK

Funding

Higher Education Commision, Pakistan nrpu-4505
6 · The paper itself

Abstract

Cisplatin is widely used in anticancer therapy, but a substantial percentage of patients who receive the therapeutic dose of cisplatin develop nephrotoxicity. Hepatotoxicity may also develop after a single dose or low repeated doses of cisplatin. Ulva fasciata is an edible seaweed, commonly known as sea lettuces have also been shown various biological activities. In this study, ethanol extract and its solvent fractions (n-hexane and chloroform) of U. fasciata were given (orally) to different groups of rats for 10 days. Injury to the kidney was induced by administrating cisplatin, intraperitoneally (i.p.) to rats at a dose of 7 mg/kg body weight (b.w.) dissolved in 1 mL saline, at 5th day of the experiment. At 10th day rats were sacrificed and kidney parameters (creatinine, urea, and blood urea nitrogen (BUN)) and electrolyte balance (Ca

Indexed as

CisplatinUlvaAnimalsAntioxidantsCreatinineEthanolGlutathioneHumansKidneyOxidative StressPlant ExtractsRatsAntioxidantsCisplatinCreatinineEthanolGlutathionePlant ExtractsCreatinineElectrolytesHepatotoxicityInflammatory cytokinesOxidative stressUrea

Identifiers

PMID33150506
OpenAlexW3097343656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.