Evidence map›Paper›PMID 33150451›Full record

ArticleRheumatology (Oxford, England)2021

High risk of coronary artery aneurysm in Kawasaki disease.

Maria Mossberg, Aladdin J Mohammad, Fredrik Kahn, Mårten Segelmark, Robin Kahn

Open access · hybridAbstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Maria MossbergSection of Pediatrics, Pediatrics, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden.
Aladdin J MohammadSection of Rheumatology, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden.
Fredrik KahnSection of Infection Medicine, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University.
Mårten SegelmarkSection of Nephrology, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University.
Robin KahnSection of Pediatrics, Pediatrics, Department of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveKawasaki disease (KD) is a vasculitis of unknown aetiology with a high risk of coronary aneurysms if untreated. Timely treatment with intravenous immunoglobulin decreases the risk for coronary artery aneurysms (CAA). In this study, we set out to elucidate the factors associated with the risk of developing CAA.

methodsRecords of all KD-diagnosed children in Skåne between 2004 and 2014 were collected and clinical and demographic data were compiled. KD is defined according to the revised American Heart Association diagnostic criteria and classified as either complete KD (cKD) or incomplete KD (iKD).

resultsKD was diagnosed in 77 children and CAA was found in 31% (n = 24). Children with CAA were younger compared with children without (median; 20 vs 34 months) and intravenous immunoglobulin treatment within 10 days was less likely to be received (75% vs 91%). In children presenting with iKD, 47% developed CAA compared with 21% in cKD patients. Using multivariate analysis, an association between the risk of CAA with low age in children with iKD was observed.

conclusionThe risk of CAA development is disturbingly high in young children with iKD. This highlights the importance of rapid intense treatment and vigilance in infants, who are the most difficult to diagnose, in order to reduce the frequency of CAA.

Indexed as

Age FactorsChildChild, PreschoolCoronary AneurysmFemaleHumansImmunoglobulins, IntravenousInfantMaleMucocutaneous Lymph Node SyndromeMultivariate AnalysisRisk FactorsSwedenImmunoglobulins, Intravenouscoronary artery aneurysmsKawasaki diseasepopulation-based studytreatment

Identifiers

PMID33150451
PMCPMC8023999
OpenAlexW3094791273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.