Observational studyInteractive cardiovascular and thoracic surgery2020
Trend in morbidity and mortality in surgical aortic valve replacement: a retrospective, observational, single-centre study.
Observational study in Interactive cardiovascular and thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The early and long-term outcomes of coronary artery bypass grafting added to aortic valve replacement compared to isolated aortic valve replacement in elderly patients: a systematic review and meta-analysis.Heart and vessels · 2022Pooled it
- Aortic Valve Interventions in Asymptomatic Severe Aortic Stenosis: Who, Why, and When?Journal of clinical medicine · 2026Review
- Predictors for and Consequences of Acute Kidney Injury After Surgical Aortic Valve Replacement: An Observational Retrospective Study.Journal of clinical medicine · 2025Article
- Initial surgery versus conservative management of chronic severe aortic regurgitation in mild symptomatic older patients.International journal of cardiology. Heart & vasculature · 2025Article
- Clinical Outcomes after Surgical Aortic Valve Replacement in 681 Octogenarians: A Single-Center Real-World Experience Comparing the Old Patients with the Very Old Patients.Geriatrics (Basel, Switzerland) · 2024Article
- Article
- Referral of Patients for Surgical Aortic Valve Replacement before and after Introduction of the Transcatheter Aortic Valve Implantation-Changing Patterns of Preoperative Characteristics and Volume and Postoperative Outcome.Journal of cardiovascular development and disease · 2023Review
- The impact of surgical training on early and long-term outcomes after isolated aortic valve surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2021Article
- Operation in the gray zone: is SAVR still useful in patients aged between 75 and 80 years?Future cardiologyArticle
- Cost of illness of Heart Valve Diseases (HVDs): A real-world analysis in Italy.Global & regional health technology assessmentArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesContinuous improvement in the management of patients undergoing surgical aortic valve replacement (SAVR) may have considerably enhanced surgical outcomes including in-hospital mortality and perioperative complications. We aimed to analyse in-hospital mortality and morbidity trends in patients undergoing SAVR in a single centre to provide insights for future benchmarking for transcatheter aortic valve implantation indications.
methodsThis was a retrospective study of prospectively collected data from patients undergoing either isolated SAVR or combined with coronary artery bypass grafting (CABG) at the Bristol Heart Institute, UK, from January 2000 to December 2017. Baseline characteristics were extracted and analysed across 3 different eras (2000-2005, 2006-2011 and 2012-2017). Risk-adjusted time trend was obtained from univariate and multivariate logistic regression including all baseline characteristics.
resultsA total of 2719 patients (63.2%) underwent isolated SAVR, and 1581 (36.8%) underwent combined CABG and SAVR during the study period. For patients undergoing SAVR, in-hospital mortality decreased from 2.9% in 2000-2005 to 0.7% in 2012-2017 (risk-adjusted time trend 0.0001). Hospital mortality in patients aged 75-79 and ≥80 years decreased from 5.6% and 5.3% to 0.4% and 2.2%, respectively. Mortality after combined SAVR and CABG did not significantly decrease (from 3.9% in 2000-2005 to 3.5% in 2012-2017; risk-adjusted time trend = 0.62). However, in patients aged ≥80 years, index hospitalization mortality showed a decreasing non-significant trend from 9.8% to 4.8%.
conclusionsOur findings support the hypothesis that mortality and morbidity rates following SAVR have significantly improved over the years, including for patients at high risk.
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