ArticleCerebral cortex (New York, N.Y. : 1991)2021
Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Effects of measurement errors on relationships between resting-state functional connectivity and psychological phenotypes.Scientific reports · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- Acupuncture on Post-Stroke Cognitive Impairment: A Systematic Review of Neuroimaging Studies.Journal of multidisciplinary healthcare · 2025Review
- Unmasking early microglial remodeling in an Alzheimer's disease mouse model.Frontiers in cellular neuroscience · 2025Article
- Temporo-frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross-cohort comparison.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age.Aging brain · 2024Article
- The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.Nature aging · 2023Article
- Associative memory is more strongly predicted by age-related differences in the prefrontal cortex than medial temporal lobes.Neuroimage. Reports · 2023Article
- The use of hippocampal grading as a biomarker for preclinical and prodromal Alzheimer's disease.Human brain mapping · 2023Article
- Longitudinal Modeling of Age-Dependent Latent Traits with Generalized Additive Latent and Mixed Models.Psychometrika · 2023Article
- Mental and physical health pathways linking insomnia symptoms to cognitive performance 14 years later.Sleep · 2023Article
- Hippocampal microstructure, but not macrostructure, mediates age differences in episodic memory.Frontiers in aging neuroscience · 2023Article
- Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults.Frontiers in aging neuroscience · 2023Article
- Higher-order multi-shell diffusion measures complement tensor metrics and volume in gray matter when predicting age and cognition.NeuroImage · 2022Article
- Change in Latent Gray-Matter Structural Integrity Is Associated With Change in Cardiovascular Fitness in Older Adults Who Engage in At-Home Aerobic Exercise.Frontiers in human neuroscience · 2022Article
- Article
- The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan.Wiley interdisciplinary reviews. Cognitive scienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintained structural integrity of hippocampal and cortical gray matter may explain why some older adults show rather preserved episodic memory. However, viable measurement models for estimating individual differences in gray matter structural integrity are lacking; instead, findings rely on fallible single indicators of integrity. Here, we introduce multitrait-multimethod methodology to capture individual differences in gray matter integrity, based on multimodal structural imaging in a large sample of 1522 healthy adults aged 60-88 years from the Berlin Aging Study II, including 333 participants who underwent magnetic resonance imaging. Structural integrity factors expressed the common variance of voxel-based morphometry, mean diffusivity, and magnetization transfer ratio for each of four regions of interest: hippocampus, parahippocampal gyrus, prefrontal cortex, and precuneus. Except for precuneus, the integrity factors correlated with episodic memory. Associations with hippocampal and parahippocampal integrity persisted after controlling for age, sex, and education. Our results support the proposition that episodic memory ability in old age benefits from maintained structural integrity of hippocampus and parahippocampal gyrus. Exploratory follow-up analyses on sex differences showed that this effect is restricted to men. Multimodal factors of structural brain integrity might help to improve our biological understanding of human memory aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.