ArticlePediatric investigation2020
Diagnosis and treatment of infantile malignant solid tumors in beijing, China: A multicenter 10-year retrospective study.
Article in Pediatric investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Direct economic burden of 0.9 million hospitalized cancer patients in Shenzhen, China, 2016-2022.BMC health services research · 2026Article
- Laryngeal mask versus intubation on adverse reactions in pediatric retinoblastoma patients.Translational pediatrics · 2025Article
- Outcome of Infantile Malignant Solid Tumors: A Single-Center Experience.Children (Basel, Switzerland) · 2025Article
- Article
- Epidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years.BMC pediatrics · 2025Article
- Current vaccination status and safety of children with peripheral neuroblastoma in the real-world.Frontiers in immunology · 2023Article
- Article
- Prevalence, clinical features and prognosis of malignant solid tumors in infants: a 14-year study.Bosnian journal of basic medical sciences · 2021Article
- Diagnosis and treatment of infantile malignant solid tumors in beijing, China: A multicenter 10-year retrospective study.Pediatric investigation · 2020Article
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20 authors at 7 institutions in 1 country.
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Abstract
importanceCancer is the main cause of death by disease in children. Children experience the highest incidence of cancer in the first year of life. However, there is no comprehensive registration system for children with tumors in China.
objectiveTo summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing, China, thereby providing evidence to guide further clinical research.
methodsFrom January 1, 2010 to December 31, 2019, patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing. The epidemiology, clinical features, and therapeutic effects of tumors in these patients were analyzed retrospectively. All patients were followed up until March 31, 2020.
resultsIn total, 938 patients were enrolled in this study. There were 530 boys (56.5%) and 408 girls (43.5%); the median age was 6.0 months (range, 0-12.0 months). The three most common tumors were retinoblastoma in 366 patients (39.0%), neuroblastoma in 266 patients (28.4%), hepatoblastoma in 133 patients (14.2%), and central nervous system tumors in 52 patients (5.5%). The estimated 5-year overall survival rate was 81.3% ± 1.8%, and the 5-year event-free survival rate was 71.8% ± 2.9%. The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma, neuroblastoma, and retinoblastoma were 100%, 88% ± 2.2%, and 86.9% ±2.1%, respectively. The 5-year event-free survival rates were 81.1% ± 2.7% for neuroblastoma, 81.6% ± 9.8% for non-rhabdomyosarcoma soft tissue sarcoma, and 72.7% ± 14.1% for extracranial malignant germ cell tumors.
interpretationThe three most common infantile malignant solid tumors were retinoblastoma, neuroblastoma, and hepatoblastoma. Multidisciplinary combined diagnosis and treatment is needed for infantile tumors.
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