ArticleMicrobial cell (Graz, Austria)2020
A novel antibacterial strategy: histone and antimicrobial peptide synergy.
Article in Microbial cell (Graz, Austria), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Fever enhances host bacterial defence while limiting mitochondrial damage.Research square · 2026Article
- Chromatin-derived histone proteins fromFrontiers in cellular and infection microbiology · 2026Article
- Isolation and partial characterization of antimicrobial peptide-enriched fractions from Parabacteroides distasonis.Scientific reports · 2025Article
- NETosis-specific cell death: a novel mechanism in the pathogenesis of gouty arthritis.European journal of medical research · 2025Review
- Article
- From inside to outside: exploring extracellular antimicrobial histone-derived peptides as multi-talented molecules.The Journal of antibiotics · 2024Review
- Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact.International journal of molecular sciences · 2023Article
- Transcriptomic identification of genes expressed in invasiveFrontiers in cellular and infection microbiology · 2023Article
- Antimicrobial peptides: Defending the mucosal epithelial barrier.Frontiers in oral health · 2022Review
- Histones: The critical players in innate immunity.Frontiers in immunology · 2022Review
- Developing Antimicrobial Synergy With AMPs.Frontiers in medical technology · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The rate at which antibiotics are discovered and developed has stagnated; meanwhile, antibacterial resistance continually increases and leads to a plethora of untreatable and deadly infections worldwide. Therefore, there is a critical need to develop new antimicrobial strategies to combat this alarming reality. One approach is to understand natural antimicrobial defense mechanisms that higher-level organisms employ in order to kill bacteria, potentially leading to novel antibiotic therapeutic approaches. Mammalian histones have long been reported to have antibiotic activity, with the first observation of their antibacterial properties reported in 1942. However, there have been doubts about whether histones could truly have any such role in the animal, predominantly based on two issues: they are found in the nucleus (so are not in a position to encounter bacteria), and their antibiotic activity
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.