ArticlePeerJ2020
Constitution of a comprehensive phytochemical profile and network pharmacology based investigation to decipher molecular mechanisms of
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Exploring the mechanism of active components from ginseng to manage diabetes mellitus based on network pharmacology and molecular docking.Scientific reports · 2023Article
- Mechanisms of Rhizoma Coptidis against type 2 diabetes mellitus explored by network pharmacology combined with molecular docking and experimental validation.Scientific reports · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundType 2 diabetes mellitus (T2DM) is a metabolic disease affecting a huge population worldwide.
methodsFor this purpose, we composed a dataset of 126 compounds for the phytochemical profile of the aerial parts of
resultsThe KEGG pathway analysis showed enrichment for the TNF signaling pathway, insulin resistance, the HIF-1 signaling pathway, apoptosis, the PI3K-AKT signaling pathway, the FOXO signaling pathway, the insulin signaling pathway, and type 2 diabetes mellitus which are related to T2DM . AKT1, IL6, STAT3, TP53, INS, and VEGFA were found to be key targets in protein-protein interaction. Besides these key targets, with this study the role of GSK3β, GLUT4, and PDX1 were also discussed through literature and considered as important targets in the antidiabetic effect of
conclusionsAccording to these findings, mainly phenolic compounds were identified as the active components and IRS1/PI3K/AKT signaling and insulin resistance were identified as the main pathways regulated by
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.