ArticleTranslational vision science & technology2020
In Vivo 3D Determination of Peripapillary Scleral and Retinal Layer Architecture Using Polarization-Sensitive Optical Coherence Tomography.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Correction method and tissue simulation approach for system polarization mode dispersion in polarization-sensitive OCT.Biomedical optics express · 2026Article
- In Vivo Evaluation of Peripapillary Scleral Architecture in Myopia and Glaucoma Using Polarization-Sensitive Optical Coherence Tomography.Investigative ophthalmology & visual science · 2026Article
- Choroidal fibrosis in secondary focal choroidal excavation detected by polarization-sensitive OCT: a report of two cases.Japanese journal of ophthalmology · 2026Article
- Possible Extension of Inner Scleral Fibers Into the Peripapillary Sclera Detected by Polarization-Sensitive OCT.Investigative ophthalmology & visual science · 2026Article
- Polarization-Interference Jones Matrix Sensors of Layer-by-Layer Scanning of Polycrystalline Dehydrated Blood Films. Fundamental and Applied Aspects.Sensors (Basel, Switzerland) · 2025Article
- Polarization-Sensitive Optical Coherence Tomography Imaging of Posterior Staphyloma Edges in Eyes With High Myopia.Investigative ophthalmology & visual science · 2025Observational
- Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera.Investigative ophthalmology & visual science · 2025Article
- Relationship Between Intraocular Pressure-Lowering Effects and Alterations in Anterior Segment Scleral Birefringence Following Micropulse Cyclophotocoagulation.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating birefringence-related image artifacts.Journal of biomedical optics · 2024Article
- Insights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach.Scientific reports · 2024Article
- Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma.Journal of clinical medicine · 2024Review
- Birefringence-derived artifact in optical coherence tomography imaging of the lamina cribrosa in eyes with glaucoma.Scientific reports · 2023Article
- Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression.Nature biomedical engineering · 2023Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.bioRxiv : the preprint server for biology · 2023Article
- Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia.Scientific reports · 2022Article
- Advances in OCT Imaging in Myopia and Pathologic Myopia.Diagnostics (Basel, Switzerland) · 2022Review
- Exploring the Cell Stemness and the Complexity of the Adipose Tissue Niche.Biomolecules · 2021Article
- Polarization-sensitive optical coherence tomography in end-stage lung diseases: an ex vivo pilot study.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this paper was to determine the architecture of the collagen fibers of the peripapillary sclera, the retinal nerve fiber layer (RNFL), and Henle's fiber layer in vivo in 3D using polarization-sensitive optical coherence tomography (PS-OCT). Methods: Seven healthy volunteers were imaged with our in-house built PS-OCT system. PS-OCT imaging included intensity, local phase retardation, relative optic axis, and optic axis uniformity (OAxU). Differential Mueller matrix calculus was used for the first time in ocular tissues to visualize local orientations that varied with depth, incorporating a correction method for the fiber orientation in preceding layers. Results: Scleral collagen fiber orientation images clearly showed an inner layer with an orientation parallel to the RNFL orientation, and a deeper layer where the collagen was circularly oriented. RNFL orientation images visualized the nerve fibers leaving the optic nerve head (ONH) in a radial pattern. The phase retardation and orientation of Henle's fiber layer were visualized locally for the first time. Conclusions: PS-OCT successfully showed the orientation of the retinal nerve fibers, sclera, and Henle's fiber layer, and is to the extent of our knowledge the only technique able to do so in 3D in vivo. Translational Relevance: In vivo 3D imaging of scleral collagen architecture and the retinal neural fibrous structures can improve our understanding of retinal biomechanics and structural alterations in different disease stages of myopia and glaucoma.
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