Evidence map›Paper›PMID 33150000›Full record

ArticleBiomedical optics express2020

Depth-resolved Mueller matrix polarimetry microscopy of the rat cornea.

V N Du Le, Ilyas Saytashev, Sudipta Saha, Pedro F Lopez, Megan Laughrey, Jessica C Ramella-Roman

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

V N Du LeDepartment of Biomedical Engineering, College of Engineering and Computing, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA.ORCID https://orcid.org/0000-0002-4054-4200
Ilyas SaytashevDepartment of Ophthalmology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.ORCID https://orcid.org/0000-0003-4213-1175
Sudipta SahaDepartment of Biomedical Engineering, College of Engineering and Computing, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA.
Pedro F LopezDepartment of Ophthalmology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
Megan LaughreyDepartment of Ophthalmology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8 Street, Miami, FL 33199, USA.
Jessica C Ramella-RomanDepartment of Biomedical Engineering, College of Engineering and Computing, Florida International University, 10555 West Flagler Street, Miami, FL 33174, USA.
Florida International University · USOSRAM (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mueller matrix polarimetry (MMP) is a promising linear imaging modality that can enable visualization and measurement of the polarization properties of the cornea. Although the distribution of corneal birefringence has been reported, depth resolved MMP imaging of the cornea has not been archived and remains challenging. In this work, we perform depth-resolved imaging of the cornea using an improved system that combines Mueller matrix reflectance and transmission microscopy together with nonlinear microscopy utilizing second harmonic generation (SHG) and two photon excitation fluorescence (TPEF). We show that TPEF can reveal corneal epithelial cellular network while SHG can highlight the presence of corneal stromal lamellae. We then demonstrate that, in confocal reflectance measurement, as depth increases from 0 to 80

Identifiers

PMID33150000
PMCPMC7587284
OpenAlexW3089064956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.