ArticleBiomedical optics express2020
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
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- Ultrahigh-resolution spectral domain optical coherence tomography with a blue-diode-pumped Ti:sapphire laser and an axicon lens.Biomedical optics express · 2025Article
- A Review of Optical Interferometry for High-Precision Length Measurement.Micromachines · 2024Review
- Precise longitudinal monitoring of corneal change through in vivo confocal microscopy in a rat dry eye disease model.Molecular vision · 2024Article
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- Line-scanning SD-OCT forBiomedical optics express · 2022Article
- Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride.Translational vision science & technology · 2022Article
- Advances in Imaging of Subbasal Corneal Nerves With Micro-Optical Coherence Tomography.Translational vision science & technology · 2021Article
- Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment.Biomedical optics express · 2021Article
- Update on imaging modalities for ocular surface pathologies.Current ophthalmology reports · 2021Article
- Advances in multimodal imaging in ophthalmology.Therapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate the highest resolution (1.5×1.5×1 µm) micrometer optical coherence tomography (µOCT) imaging of the morphologic micro-structure of excised swine and non-human primate corneas. Besides epithelial, stromal, and endothelial cell morphology, this report focuses on investigating the most peripheral corneal nerve fibers, the nerve fibers of the subbasal plexus (SBP). Alterations of SBP nerve density and composition are reportedly linked to major neurologic disorders, such as diabetic neuropathy, potentially indicating earliest onsets of denervation. Here, the fine, hyperreflective, epithelial nerve structures located just above Bowman's membrane, are i) visualized using our µOCT prototype, ii) validated by comparison to fluorescence confocal microscopy (including selective immunohistochemical staining), and iii) segmented using state-of-the-art image processing. Here, we also introduce polarization sensitive (PS) µOCT imaging, demonstrating, to the best of our knowledge, the highest resolution corneal PS-OCT scans reported to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.