Evidence map›Paper›PMID 33149989›Full record

ArticleBiomedical optics express2020

Effect of vascular structure on laser speckle contrast imaging.

Chakameh Z Jafari, Colin T Sullender, David R Miller, Samuel A Mihelic, Andrew K Dunn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chakameh Z JafariDepartment of Electrical and Computer Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Colin T SullenderDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.ORCID https://orcid.org/0000-0003-4329-7708
David R MillerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Samuel A MihelicDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Andrew K DunnDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.

Funding

Optical Imaging of Baseline Blood Flow and Oxygenation During StrokeR01EB011556 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2010 to 2018
$3.1M
Longitudinal Imaging of Cortical Small Vessel Network Structure with Two-Color Multiphoton Fluorescence MicroscopyR01NS108484 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2018 to 2022
$2.8M
Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
Microscale Oxygenation Mapping During StrokeR01NS082518 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2013 to 2017
$1.7M
NIBIB NIH HHS R01 EB011556NIBIB NIH HHS T32 EB007507NINDS NIH HHS R01 NS082518NINDS NIH HHS R01 NS108484
6 · The paper itself

Abstract

Laser speckle contrast imaging (LSCI) is a powerful tool for non-invasive, real-time imaging of blood flow in tissue. However, the effect of tissue geometry on the form of the electric field autocorrelation function and speckle contrast values is yet to be investigated. In this paper, we present an ultrafast forward model for simulating a speckle contrast image with the ability to rapidly update the image for a desired illumination pattern and flow perturbation. We demonstrate the first simulated speckle contrast image and compare it against experimental results. We simulate three mouse-specific cerebral cortex decorrelation time images and implement three different schemes for analyzing the effects of homogenization of vascular structure on correlation decay times. Our results indicate that dissolving structure and assuming homogeneous geometry creates up to ∼ 10x shift in the correlation function decay times and alters its form compared with the case for which the exact geometry is simulated. These effects are more pronounced for point illumination and detection imaging schemes, highlighting the significance of accurate modeling of the three-dimensional vascular geometry for accurate blood flow estimates.

Identifiers

PMID33149989
PMCPMC7587253

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.