Evidence map›Paper›PMID 33149940›Full record

ArticleRegenerative biomaterials2020

Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair.

Yuzhu He, Yahui Jin, Xiaoxia Ying, Qiong Wu, Shenglian Yao, Yuanyuan Li, Huiying Liu, Guowu Ma, Xiumei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yuzhu HeState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Yahui JinState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Xiaoxia YingDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Lvshun South Road, Lushunkou District, Dalian 116044, China.
Qiong WuSchool of Life Sciences, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Shenglian YaoState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Yuanyuan LiState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Huiying LiuDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Lvshun South Road, Lushunkou District, Dalian 116044, China.ORCID 0000-0002-0385-3557
Guowu MaDepartment of Oral Prosthodontics, School of Stomatology, Dalian Medical University, Lvshun South Road, Lushunkou District, Dalian 116044, China.
Xiumei WangState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Zhongguancun Street, Haidian District, Beijing 100084, China.
Dalian Medical University · CNState Key Laboratory of New Ceramics and Fine ProcessingTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of infective bone defects is a great challenge in clinical work. It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration. A porous mineralized collagen (MC) scaffold containing poly(d,l-lactide-co-glycolic acid) (PLGA) microspheres loaded with two antibacterial synthetic peptides, Pac-525 or KSL-W was developed and characterized via scanning electron microscopy (SEM), porosity measurement, swelling and mechanical tests. The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties. Through toxicity analysis, cell morphology and proliferation analysis and alkaline phosphatase evaluation, the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity. The antibacterial property evaluated with

Indexed as

antibacterial peptidesmineralized collagen scaffoldosteogenic differentiationPLGA microspheres

Identifiers

PMID33149940
PMCPMC7597801
OpenAlexW3019024864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.