Evidence map›Paper›PMID 33149930›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI.

Riccardo Galbusera, Katrin Parmar, Yohan Boillat, Mario Joao Fartaria, Alexandra-Ramona Todea, Kieran O' Brien, Anna Smolinski, Ludwig Kappos, Wietske van der Zwaag, Cristina Granziera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Riccardo GalbuseraNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-3092-8737
Katrin ParmarNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Yohan BoillatLaboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Mario Joao FartariaAdvanced Clinical Imaging Technology, Siemens Healthcare AG (HC CMEA SUI DI BM PI), Lausanne, Switzerland.
Alexandra-Ramona TodeaTranslational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Kieran O' BrienSiemens Healthcare Pty Ltd., Bowen Hills, Australia; Centre for Advanced Imaging, University of Queensland, Australia.
Anna SmolinskiTranslational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Ludwig KapposNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-4175-5509
Wietske van der ZwaagSpinoza Centre for Neuroimaging, Amsterdam, Netherlands.
Cristina GranzieraNeurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
University of Basel · CHÉcole Polytechnique Fédérale de Lausanne · CHSpinoza Centre for Neuroimaging · NLThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS.

objectiveThe aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those changes on clinical performance.

methodsEighteen RRMS patients and nine healthy controls underwent quantitative T

resultsThe volume of the cerebellar cortex and its layers did not differ between patients and controls. In MS patients, significantly longer T

conclusionsWe found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes. This microstructural alteration appears to be related to EDSS and cognitive performance.

Indexed as

cerebellumMRIMultiple sclerosisultra-high field MRI

Identifiers

PMID33149930
PMCPMC7586276
OpenAlexW3094409355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.