Evidence map›Paper›PMID 33149806›Full record

ArticleOxidative medicine and cellular longevity2020

Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression.

Ningle Wei, Liuyi Lu, Huanji Zhang, Ming Gao, Sounak Ghosh, Zhaoyu Liu, Junhua Qi, Jingfeng Wang, Jie Chen, Hui Huang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ningle WeiGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0001-7207-1615
Liuyi LuGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-4795-7160
Huanji ZhangDepartment of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.ORCID https://orcid.org/0000-0003-2920-2928
Ming GaoDepartment of Radiation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-4602-4393
Sounak GhoshGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0003-4245-0811
Zhaoyu LiuGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0002-2754-8661
Junhua QiDepartment of Pharmacy, Guangzhou Women and Children' s Medical Center, Guangzhou 510120, China.ORCID https://orcid.org/0000-0002-4425-8682
Jingfeng WangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0002-5827-7876
Jie ChenDepartment of Radiotherapy, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.ORCID https://orcid.org/0000-0002-1678-3586
Hui HuangDepartment of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.ORCID https://orcid.org/0000-0001-5716-4012
Sun Yat-sen University · CNGuangzhou Women and Children Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Warfarin, a vitamin K antagonist (VKA), is known to promote arterial calcification (AC). In the present study, we conducted a case-cohort study within the Multi-Ethnic Study of Atherosclerosis (MESA); 6655 participants were included. From MESA data, we found that AC was related to both age and vitamin K; furthermore, the score of AC increased with SASP marker including interlukin-6 (IL-6) and tumor necrosis factor alpha (TNF-

Indexed as

AbdomenAgedAnimalsAortic ValveAtrial FibrillationBiomarkersCellular SenescenceDose-Response Relationship, DrugElectrocardiographyFactor Analysis, StatisticalFemaleHumansInterleukin-6Logistic ModelsMaleMiddle AgedBiomarkersInterleukin-6PhosphatesVitamin KWarfarin

Identifiers

PMID33149806
PMCPMC7603623
OpenAlexW3094125425

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.