Evidence map›Paper›PMID 33149788›Full record

ReviewExperimental and therapeutic medicine2020

Research and prospect of peptides for use in obesity treatment (Review).

Yao Gao, Xuewen Yuan, Ziyang Zhu, Dandan Wang, Qianqi Liu, Wei Gu

Open access · diamondAbstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anti-obesity peptides from food: Production, evaluation, sources, and commercialization.Comprehensive reviews in food science and food safety · 2025
    Review
  5. The Role of Peptides in Asthma-Obesity Phenotype.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yao GaoDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Xuewen YuanDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Ziyang ZhuDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Dandan WangDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Qianqi LiuDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Wei GuDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Second Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and its related diseases, such as type 2 diabetes, hypertension and cardiovascular disease, are steadily increasing worldwide. Over the past few decades, numerous studies have focused on the differentiation and function of brown and beige fat, providing evidence for their therapeutic potential in treating obesity. However, no specific novel drug has been developed to treat obesity in this way. Peptides are a class of chemically active substances, which are linked together by amino acids using peptide bonds. They have specific physiological activities, including browning of white fat. As signal molecules regulated by the neuroendocrine system, the role of polypeptides, such as neuropeptide Y, brain-gut peptide and glucagon-like peptide in obesity and its related complications has been revealed. Notably, with the rapid development of peptidomics, peptide drugs have been widely used in the prevention and treatment of metabolic diseases, due to their short half-life, small apparent distribution volume, low toxicity and low side effects. The present review summarizes the progress and the new trend of peptide research, which may provide novel targets for the prevention and treatment of obesity.

Indexed as

metabolic diseasesobesitypeptidespeptidomicstreatment

Identifiers

PMID33149788
PMCPMC7604735
OpenAlexW3093114542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.