Evidence map›Paper›PMID 33149778›Full record

ArticleExperimental and therapeutic medicine2020

Endurance of erythrocyte series in chemotherapy.

Sorin Săftescu, Dorel Popovici, Cristina Oprean, Alina Negru, Adina Croitoru, Mihail Zemba, Ionela Yasar, Maria Preda, Șerban Negru

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Uveal melanoma diagnosis and current treatment options (Review).Experimental and therapeutic medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sorin SăftescuDepartment of Oncology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Dorel PopoviciDepartment of Oncology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Cristina OpreanDepartment of Oncology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Alina NegruDepartment of Cardiology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Adina CroitoruDepartment of Medical Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Mihail ZembaDepartment of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Ionela YasarDepartment of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Maria PredaDepartment of Ophthalmology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Șerban NegruDepartment of Oncology, 'Victor Babe?' University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Victor Babeș University of Medicine and Pharmacy Timișoara · ROCarol Davila University of Medicine and Pharmacy · ROInstitutul Clinic Fundeni · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic bone marrow toxicity is most often the limiting factor for chemotherapy doses. Increasing the intensity of chemotherapy doses (higher doses or more frequent administration) would improve antitumor effects, but the hematological toxicity does not allow these dose increases. This study evaluated the impact of chemotherapies on the parameters belonging to the red blood cell series in the hemogram and aimed to identify some particular evolution profiles. We selected 855 evaluations performed before the administration of chemotherapy belonging to the treatments initiated during the period December 2018-February 2020, containing 5-fluorouracil, cisplatin, docetaxel, epirubicin or pemetrexed. The data of the 644 evaluations related to the cycles 1-4 of chemotherapy were subject to this processing. The average relative loss of hemoglobin is -11% after the first three cycles of treatment, with statistically significant differences in hemoglobin levels in favor of men. There are risk factors associated with higher average losses, such as age <50 years or >65 years (statistically significant), body mass index (BMI) >25, cisplatin treatment (insufficient number of cases to reach statistical significance).

Indexed as

bone marrowcancerchemotherapyerythrocyteshaemoglobin

Identifiers

PMID33149778
PMCPMC7604759
OpenAlexW3093067902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.