Evidence map›Paper›PMID 33149761›Full record

ReviewTherapeutic advances in gastroenterology2020

Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention.

Charlotte Skinner, Alex J Thompson, Mark R Thursz, Julian R Marchesi, Nikhil Vergis

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  8. Microbiota composition and intestinal barrier function modulated by tamsulosin andFrontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charlotte SkinnerDepartment of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
Alex J ThompsonDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, UK.
Mark R ThurszDepartment of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
Julian R MarchesiDepartment of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
Nikhil VergisDepartment of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, W2 1NY, UK.ORCID https://orcid.org/0000-0002-9815-0917
St Mary's Hospital · GB

Funding

Medical Research Council MR/R014019/1
6 · The paper itself

Abstract

Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.

Indexed as

alcohol-related liver diseasebacterial translocationcirrhosisgut barrierintestinal permeability

Identifiers

PMID33149761
PMCPMC7580143
OpenAlexW3092951630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.