Evidence map›Paper›PMID 33149572›Full record

ArticleInternational journal of nanomedicine2020

Graphene Oxide/Copper Nanoderivatives-Modified Chitosan/Hyaluronic Acid Dressings for Facilitating Wound Healing in Infected Full-Thickness Skin Defects.

Ying Yang, Zhonggen Dong, Min Li, Lihong Liu, Hang Luo, Pu Wang, Dou Zhang, Xinghua Yang, Kechao Zhou, Shaorong Lei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 55 citations in OpenAlex.

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  13. Microenvironment-Based Diabetic Foot Ulcer Nanomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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  18. [Application of functional materials to promote cutaneous wound healing].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ying YangState Key Laboratory of Powder Metallurgy, Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China.
Zhonggen DongDepartment of Orthopedic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, People's Republic of China.
Min LiDepartment of Oncology, Changsha Central Hospital, University of South China, Changsha 410004, People's Republic of China.
Lihong LiuState Key Laboratory of Powder Metallurgy, Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China.
Hang LuoState Key Laboratory of Powder Metallurgy, Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China.
Pu WangDepartment of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Dou ZhangState Key Laboratory of Powder Metallurgy, Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China.
Xinghua YangDepartment of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Kechao ZhouState Key Laboratory of Powder Metallurgy, Research Institute of Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China.
Shaorong LeiDepartment of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNChangsha Central Hospital · CNState Key Laboratory of Powder MetallurgyXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWound healing, especially of infected wounds, remains a clinical challenge in plastic surgery. This study aimed to manufacture a novel and multifunctional wound dressing by combining graphene oxide/copper nanocomposites (GO/Cu) with chitosan/hyaluronic acid, providing significant opportunities for the therapy of wound repair in wounds with a high risk of bacterial infection.

methodsIn this study, GO/Cu-decorated chitosan/hyaluronic acid dressings (C/H/GO/Cu) were prepared using sodium trimetaphosphate (STMP) crosslinking and the vacuum freeze-drying method, and chitosan/hyaluronic acid dressings (C/H) and GO-incorporated chitosan/hyaluronic acid dressings (C/H/GO) served as controls. The surface characterization, in vitro degradation under various pH values, antimicrobial potential, cytocompatibility and in vivo therapeutic efficacy in a bacteria-infected full-thickness skin defect model were systematically evaluated.

resultsOur experimental results indicated that the acidic environment facilitated the release of copper (CuNPs and Cu

conclusionCollectively, GO/Cu-incorporated chitosan/hyaluronic acid dressings suggested a synergistic antimicrobial efficacy and acceptable biocompatibility both in vitro and in vivo, as well as a significantly accelerated healing process of bacteria-infected wounds. Thus, the multifunctional C/H/GO/Cu composite is expected to be a potential alternative for wound dressings, especially for the management of intractable wounds caused by bacterial infection.

Indexed as

Bandages3T3-L1 CellsAnimalsAnti-Bacterial AgentsBacterial InfectionsChitosanCopperGraphiteHyaluronic AcidMaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsNanocompositesNanostructuresSkinAnti-Bacterial AgentsChitosanCoppergraphene oxideGraphiteHyaluronic Acidbacterial infectioncopper nanoparticlesgraphene oxidewound dressingwound healing

Identifiers

PMID33149572
PMCPMC7604465
OpenAlexW3096967334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.