Evidence map›Paper›PMID 33149480›Full record

ArticleJournal of pharmacy & bioallied sciences2020

A Case-control Study Comparing and Correlating iNOS Expression among Various Clinicopathological Variants of Oral Leukoplakia and Oral Squamous Cell Carcinoma: A Immunohistochemistry Study.

Deepak N Singh, Kumar Chandan Srivastava, Aparna D Potsangbam, Deepti Shrivastava, Doddabasavaiah Basavapur Nandini, Wahengbam T Singh, Koijam S Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Deepak N SinghDepartment of Oral Medicine and Radiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Kumar Chandan SrivastavaDepartment of Oral & Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, Jouf University, Sakakah, Kingdom of Saudi Arabia.
Aparna D PotsangbamDepartment of Oral Pathology& Microbiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Deepti ShrivastavaDepartment of Preventive Dentistry, College of Dentistry, Jouf University, Sakakah, Kingdom of Saudi Arabia.
Doddabasavaiah Basavapur NandiniDepartment of Oral Pathology& Microbiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Wahengbam T SinghDepartment of Oral Maxillofacial Surgery, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Koijam S SinghDepartment of Oral Medicine and Radiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Regional Institute of Medical Sciences · INAl Jouf University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe role of inducible nitric oxide synthase (iNOS) has been implicated in various pathological processes including oral carcinoma. Oral premalignancy being its precursor lesion is also expected to show similar pattern. This study attempts to appraise the iNOS expression in various clinicopathological stages and grades of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). MATERIALS AND

methodsA case-control study design was adopted for this study with a total sample of 90 subjects, distributed equally into the three study groups, namely controls, OL, and OSCC. Clinical staging and histopathological grading for both the case groups were performed. Representative tissue samples from all groups were obtained and studied for iNOS expression using immunohistochemistry (IHC). Data were presented in mean and percentages accordingly. Inferential analysis was performed using Kruskal-Wallis test, Mann-Whitney test, and Spearman rank correlation test.

resultsSignificant (

conclusionIncreased expression of iNOS can be an early diagnostic marker in OL and as prognostic marker in OSCC.

Indexed as

Immunohistochemistry staininginducible nitric oxide synthasenitric oxide synthaseoral canceroral premalignant

Identifiers

PMID33149480
PMCPMC7595486
OpenAlexW3081094768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.