Evidence map›Paper›PMID 33149468›Full record

ArticleJournal of pharmacy & bioallied sciences2020

Evaluation of the Efficacy of Loricrin as a Diagnostic Marker in Patients with Oral Submucous Fibrosis.

Niva Mahapatra, Kailash C Dash, Lipsa Bhuyan, Abikshyeet Panda, Shyam S Behura, Pallavi Mishra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Niva MahapatraDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Kailash C DashDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Lipsa BhuyanDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Abikshyeet PandaDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Shyam S BehuraDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Pallavi MishraDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology, Deemed to Be University, Bhubaneswar, Odisha, India.
Christie's · GBKIIT University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLoricrin is usually observed in abundance in keratinizing epithelium in response to mechanical stress, which may be associated with development and malignant transformations in conditions such as oral submucous fibrosis (OSMF). Therefore, understanding of various molecular mechanisms associated with difference in gene expressions between OSMF and that of normal oral tissue is important.

aimThe aim of this study was to evaluate of the efficacy of loricrin as a diagnostic marker in patients with OSMF. MATERIALS AND

methodsFifty formalin-fixed paraffin-embedded tissue blocks were obtained from the archives of the department. The study sample was grouped into two groups of normal mucosa (group I;

resultsLoricrin immunostaining was observed significantly more in OSMF cases and even in stratum granulosum in comparison to normal mucosa.

conclusionLoricrin can act as an early indicator and a prognostic marker for detection of deleterious changes within epithelium in OSMF.

Indexed as

Areca nutimmunohistochemistryloricrinnormal mucosaoral submucous fibrosis

Identifiers

PMID33149468
PMCPMC7595509
OpenAlexW3080405831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.