ArticleNature2020
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 112 papers.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 167 citations in OpenAlex.
- Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026Review
- Targeting Elastin-Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease.MedComm · 2026Article
- Defective alveolar regeneration in emphysema: identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Ageing-associated regenerative failure in the lung: stem cell senescence and transitional cell persistence in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.Cell · 2026Article
- The formation and function of tertiary lymphoid structures.Biomarker research · 2026Review
- Epithelial cells in chronic obstructive pulmonary disease exacerbations: Targets for lung repair.Pharmacological reviews · 2026Review
- Regenerative therapeutics for chronic obstructive pulmonary disease.Pharmacological reviews · 2026Review
- Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity.Cell death & disease · 2026Article
- Lymphotoxin-beta receptor controls the development of chronic pain.Cell reports · 2026Article
- TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.The EMBO journal · 2026Article
- Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD.EMBO molecular medicine · 2026Article
- Context-specific roles for IL-17 in tuberculosis.PLoS pathogens · 2026Review
- Guominkang formula alleviates airway inflammation in HDM-induced asthma mice by regulating Wnt/β-Catenin pathway.Chinese medicine · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease.Nature genetics · 2026Article
- TNF superfamily member 14 drives post-influenza depletion of alveolar macrophages, enabling secondary pneumococcal pneumonia.The Journal of clinical investigation · 2026Article
- Helping alveolar macrophages live to fight another day during viral pneumonia.The Journal of clinical investigation · 2026Article
- Pleiotropic and multicellular roles of lymphotoxin beta receptor in solid tumor immunity and therapeutic targeting.Frontiers in immunology · 2026Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
49 authors at 10 institutions in 5 countries.
Thomas M Conlon *Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4316-6612
Gerrit John-Schuster *Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Danijela HeideGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Dominik PfisterGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0542-2638
Mareike LehmannComprehensive Pneumology Center (CPC), Lung Repair and Regeneration Research Unit, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Yan HuDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, CO, USA.
Zeynep ErtüzComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Martin A LopezLaboratory of Molecular Immunology and Signal Transduction, GIGA-Institute, University of Liège, Liège, Belgium.
Meshal AnsariComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8819-7965
Maximilian StrunzComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Christoph MayrComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Ilias AngelidisComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Chiara CiminieriDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, CO, USA.
Rita CostaComprehensive Pneumology Center (CPC), Lung Repair and Regeneration Research Unit, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0003-0710-3611
Marlene Sophia KohlheppDepartment of Hepatology & Gastroenterology, Charité University Medicine Berlin, Berlin, Germany.
Adrien GuillotDepartment of Hepatology & Gastroenterology, Charité University Medicine Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-6002-9986
Gizem GünesComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Aicha JeridiComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.
Maja C FunkGerman Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6007-1164
Giorgi BeroshviliComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8038-1493
Sandra ProkoschGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Jenny HetzerGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Stijn E VerledenDivision of Pneumology, KU Leuven, Leuven, Belgium.
Hani AlsafadiComprehensive Pneumology Center (CPC), Lung Repair and Regeneration Research Unit, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0002-1186-2517
Michael LindnerAsklepios Fachkliniken Munich-Gauting, Member of the German Center for Lung Research (DZL), Munich, Germany.
Gerald BurgstallerComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-7121-2567
Lore BeckerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Martin IrmlerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3169-479X
Michael DudekInstitute of Molecular Immunology & Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jakob JanzenGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Eric GoffinLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Liège, Belgium.
Reinoud GosensDepartment of Molecular Pharmacology, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-5595-152X
Percy KnolleInstitute of Molecular Immunology & Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-2983-0414
Bernard PirotteLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0001-8251-8257
Tobias StoegerComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-2790-0389
Johannes BeckersInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Darcy WagnerComprehensive Pneumology Center (CPC), Lung Repair and Regeneration Research Unit, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0003-3794-1309
Indrabahadur SinghEmmy Noether Research Group Epigenetic Machineries and Cancer, Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fabian J TheisInstitute of Computional Biology (ICB), Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-2419-1943
Martin Hrabé de AngelisInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-7898-2353
Tracy O'ConnorGerman Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Frank TackeDepartment of Hepatology & Gastroenterology, Charité University Medicine Berlin, Berlin, Germany.
Michael BoutrosGerman Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Germany.
Emmanuel DejardinLaboratory of Molecular Immunology and Signal Transduction, GIGA-Institute, University of Liège, Liège, Belgium.
Oliver EickelbergDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, CO, USA.
Herbert B SchillerComprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany.ORCID http://orcid.org/0000-0001-9498-7034
Melanie KönigshoffComprehensive Pneumology Center (CPC), Lung Repair and Regeneration Research Unit, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0001-9414-5128
Mathias Heikenwalder *German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Heidelberg, Germany. m.heikenwaelder@dkfz.de.ORCID http://orcid.org/0000-0002-3135-2274
Ali Önder Yildirim *Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Neuherberg, Germany. oender.yildirim@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0003-1969-480X
Helmholtz Zentrum München · DEGerman Cancer Research Center · DEUniversity of Liège · BECharité - Universitätsmedizin Berlin · DELund University · SETUM Klinikum · DEUniversity of Colorado Denver · USUniversity of Groningen · NLAsklepios Fachkliniken München-Gauting · DEKU Leuven · BE
Funding
Non-canonical WNT signaling in emphysema and lung regenerationR01HL141380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOENIGSHOFF, MELANIE · 2019 to 2022
$2.1MIdentification of a Wnt/ Beta-catenin responsive adult lung epithelial progenitor cell for tissue repair in chronic lung diseaseF32HL149290 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HU, YAN · 2019 to 2021
$208kNHLBI NIH HHS F32 HL149290NHLBI NIH HHS R01 HL141380
Abstract
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures
Indexed as
Adaptive ImmunityAgingAlveolar Epithelial CellsAnimalsApoptosisbeta CateninEmphysemaFemaleHumansImmunity, InnateLungLymphotoxin beta ReceptorMiceMice, Inbred C57BLNF-kappa BPulmonary Disease, Chronic Obstructivebeta CateninLTBR protein, humanLtbr protein, mouseLymphotoxin beta ReceptorNF-kappa BSmokeWnt Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.