ArticleNature2020
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 139 citations in OpenAlex.
- Integrated Investigation of Sex Differences in the Human Nociceptin/Orphanin FQ Receptor System: Postmortem Analyses and In Vivo [Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Efficient experimental characterization of the GPCRome via deep receptor scanning.Nature communications · 2026Article
- Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors.Nature communications · 2026Article
- Dopamine D2 Receptor Isoform Heteroreceptor Complexes with the Growth Hormone Secretagogue Receptor 1a Reveals Isoform-Specific Interaction Interface Dynamics.Journal of chemical information and modeling · 2026Article
- Dietary anthocyanidin pelargonidin activates G protein-coupled receptor 35.The FEBS journal · 2026Article
- Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.Nature biotechnology · 2026Article
- Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury.Bone research · 2026Review
- Functional CCR7A-mediated cellular responses are negatively modulated by the splice variant CCR7B.PloS one · 2026Article
- Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale.Nature methods · 2026Article
- GPCR systems coordinate cellular resilience against aging-associated stress.Frontiers in molecular biosciences · 2026Review
- Receptor activity-modifying protein 3 enhances GLP-1-mediated insulin secretion.The Journal of biological chemistry · 2025Article
- Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis.bioRxiv : the preprint server for biology · 2025Article
- Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide YNature communications · 2025Article
- G protein-coupled receptors: pivotal hubs in gastric cancer malignancy-from multidimensional crosstalk to precision therapeutics.Journal of translational medicine · 2025Review
- Modulating the Properties of GPCR-Based Sensors Via C-Terminus Isoforms.ACS synthetic biology · 2025Article
- GABAiScience · 2025Article
- Personalized medicine for cancer cachexia via the ghrelin receptor.Nature structural & molecular biology · 2025Article
- Toward a comprehensive profiling of alternative splicing proteoform structures, interactions and functions.Current opinion in structural biology · 2025Review
- Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism.Cell research · 2025Article
- C1orf115 interacts with clathrin adaptors to undergo endocytosis and induces ABCA1 to promote enteric cholesterol efflux.Cellular and molecular life sciences : CMLS · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 6 institutions in 3 countries.
Maria Marti-SolanoMRC Laboratory of Molecular Biology, Cambridge, UK. mmarti@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0003-0373-8927
Stephanie E CrillyCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Duccio MalinverniMRC Laboratory of Molecular Biology, Cambridge, UK.
Christian MunkDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Matthew HarrisDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Abigail PearceDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9845-0541
Tezz QuonCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Amanda E MackenzieCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Xusheng WangCenter for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.
Junmin PengCenter for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-0472-7648
Andrew B TobinCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-1807-3123
Graham LaddsDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7320-9612
Graeme MilliganCentre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-6946-3519
David E GloriamDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4299-7561
Manojkumar A PuthenveeduCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3177-4231
M Madan BabuMRC Laboratory of Molecular Biology, Cambridge, UK. madan.babu@stjude.org.ORCID http://orcid.org/0000-0003-0556-6196
St. Jude Children's Research Hospital · USUniversity of Glasgow · GBUniversity of Cambridge · GBUniversity of Copenhagen · DKUniversity of Michigan · USMRC Laboratory of Molecular Biology · GB
Funding
Multi-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2MMECHANISMS ENSURING SEQUENCE-DEPENDENT GPCR RECYCLINGR01GM117425 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 2016 to 2020
$1.5MEuropean Research CouncilMedical Research Council MC_PC_17156Medical Research Council MC_U105185859NIA NIH HHS R01 AG053987NIGMS NIH HHS R01 GM117425NIH HHS GM117425Wellcome Trust 201529/Z/16/Z
Abstract
G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence
Indexed as
TranscriptomeDatabases, FactualGene Expression ProfilingHEK293 CellsHumansMolecular Targeted TherapyOrgan SpecificityProtein IsoformsProteomicsReceptors, G-Protein-CoupledSignal TransductionSingle-Cell AnalysisProtein IsoformsReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.