Evidence map›Paper›PMID 33149302›Full record

ArticleNature2020

Gut-educated IgA plasma cells defend the meningeal venous sinuses.

Zachary Fitzpatrick, Gordon Frazer, Ashley Ferro, Simon Clare, Nicolas Bouladoux, John Ferdinand, Zewen Kelvin Tuong, Maria Luciana Negro-Demontel, Nitin Kumar, Ondrej Suchanek and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 1 synthesis or guideline pooled it, 284 citations in OpenAlex.

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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Zachary FitzpatrickMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Gordon FrazerMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Ashley FerroMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.
Simon ClareHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Nicolas BouladouxNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.
John FerdinandMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0936-0128
Zewen Kelvin TuongMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6735-6808
Maria Luciana Negro-DemontelViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MA, USA.
Nitin KumarHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-2140-4923
Ondrej SuchanekMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1048-5251
Tamara TajsicDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Katherine HarcourtHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Kirsten ScottMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3121-5963
Rachel Bashford-RogersWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Adel HelmyDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0531-0556
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MA, USA.ORCID http://orcid.org/0000-0002-2628-4334
Yasmine BelkaidNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.ORCID http://orcid.org/0000-0001-9962-3571
Trevor D LawleyHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-4805-621X
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MA, USA. mcgavernd@mail.nih.gov.ORCID http://orcid.org/0000-0001-9568-545X
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK. mrc38@cam.ac.uk.
University of Cambridge · GBNational Institutes of Health · USWellcome Sanger Institute · GBCentre for Human Genetics · GBMRC Laboratory of Molecular Biology · GB

Funding

Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6M
Mechanisms Underlying Clearance of the Persistently Infected CNSZIANS003111 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.0M
Intramural NIH HHS ZIA NS003111Intramural NIH HHS ZIA NS003112Medical Research Council G0802251Medical Research Council MR/N024907/1
6 · The paper itself

Abstract

The central nervous system has historically been viewed as an immune-privileged site, but recent data have shown that the meninges-the membranes that surround the brain and spinal cord-contain a diverse population of immune cells

Indexed as

AgedAgingAnimalsBlood-Brain BarrierCranial SinusesFemaleFungiGastrointestinal MicrobiomeGerm-Free LifeHumansImmunoglobulin A, SecretoryIntestinesMaleMeningesMiceMice, Inbred C57BLImmunoglobulin A, Secretory

Identifiers

PMID33149302
PMCPMC7748383
OpenAlexW3095091383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.